Reactome | p-TIAM1 exchanges GTP for GDP on RAC1, activating it

Schema > Reaction > Entries

p-TIAM1 exchanges GTP for GDP on RAC1, activating it Show undefined attributes

catalystActivity	[CatalystActivity:10616076] guanyl-nucleotide exchange factor activity of EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
dbId	10616078
displayName	p-TIAM1 exchanges GTP for GDP on RAC1, activating it
eventOf	[Pathway:R-GGA-3928662] EPHB-mediated forward signaling - Gallus gallus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-4093336] p-TIAM1 exchanges GTP for GDP on RAC1, activating it - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-GGA-445010] RAC1:GDP [cytosol]
isInDisease	false
isInferred	true
name	p-TIAM1 exchanges GTP for GDP on RAC1, activating it
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-GGA-442641] RAC1:GTP [plasma membrane]
precedingEvent	[Reaction:R-GGA-3928627] EPHB phosphorylates TIAM1 - Gallus gallus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-4093336
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-3928662] EPHB-mediated forward signaling
(inferredTo)	[Reaction:R-HSA-4093336] p-TIAM1 exchanges GTP for GDP on RAC1, activating it