Reactome | EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK

Schema > Reaction > Entries

EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK Show undefined attributes

catalystActivity	[CatalystActivity:10583593] protein serine/threonine kinase activity of PERK dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
dbId	10583595
displayName	EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK
eventOf	[Pathway:R-GGA-381042] PERK regulates gene expression - Gallus gallus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-GGA-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol]
isInDisease	false
isInferred	true
name	EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-GGA-9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]
precedingEvent	[Reaction:R-GGA-381087] Dimerization of PERK - Gallus gallus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-381111
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-381042] PERK regulates gene expression
(inferredTo)	[Reaction:R-HSA-381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK

Cite Us!