Reactome | p-S166,S188-MDM2 dimer [nucleoplasm]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10471755] ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-DRE-8952373] RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm] - Danio rerio
consumedByEvent	[Reaction:R-DRE-8952371] MDM2 binds RUNX3 - Danio rerio [Reaction:R-DRE-6804942] MDM2 homodimers auto-ubiquitinate - Danio rerio
created	[InstanceEdit:10427439] Wright, Adam, 2024-03-07
dbId	10464196
displayName	p-S166,S188-MDM2 dimer [nucleoplasm]
hasComponent	2 × [EntityWithAccessionedSequence:R-DRE-6793669] phospho-mdm2 [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-6804933] p-S166,S188-MDM2 dimer [nucleoplasm] - Homo sapiens
memberOf	[DefinedSet:R-DRE-6804745] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] - Danio rerio
name	p-S166,S188-MDM2 dimer
producedByEvent	[Reaction:R-DRE-8952382] MDM2 polyubiquitinates RUNX3 - Danio rerio
schemaClass	Complex
species	[Species:68323] Danio rerio
stId	R-DRE-6804933
summation	[Summation:9864367] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-DRE-8952382] MDM2 polyubiquitinates RUNX3
(activeUnit)	[CatalystActivity:10477863] ubiquitin protein ligase activity of RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm]
(input)	[Reaction:R-DRE-8952371] MDM2 binds RUNX3 [Reaction:R-DRE-6804942] MDM2 homodimers auto-ubiquitinate
(hasComponent)	[Complex:R-DRE-8952373] RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm]
(physicalEntity)	[CatalystActivity:10471755] ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer [nucleoplasm]
(hasMember)	[DefinedSet:R-DRE-6804745] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]
(inferredTo)	[Complex:R-HSA-6804933] p-S166,S188-MDM2 dimer [nucleoplasm]