Reactome | Activated FGFR3 binds PLCG1

Schema > Reaction > Entries

Activated FGFR3 binds PLCG1 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10427439] Wright, Adam, 2024-03-07
dbId	10464600
displayName	Activated FGFR3 binds PLCG1
eventOf	[Pathway:R-DRE-5654227] Phospholipase C-mediated cascade; FGFR3 - Danio rerio
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-5654222] Activated FGFR3 phosphorylates PLCG1 - Danio rerio
inferredFrom	[Reaction:R-HSA-5654224] Activated FGFR3 binds PLCG1 - Homo sapiens
input	[DefinedSet:R-DRE-5654146] Activated FGFR3 [plasma membrane] [EntityWithAccessionedSequence:R-DRE-167682] fj46f04 [plasma membrane] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isInDisease	false
isInferred	true
name	Activated FGFR3 binds PLCG1
output	[Complex:R-DRE-5654226] activated FGFR3:PLCG1 [plasma membrane]
precedingEvent	[Reaction:R-DRE-190385] Autocatalytic phosphorylation of FGFR3b - Danio rerio [Reaction:R-DRE-190388] Autocatalytic phosphorylation of FGFR3c - Danio rerio
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-5654224
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-5654227] Phospholipase C-mediated cascade; FGFR3
(precedingEvent)	[Reaction:R-DRE-5654222] Activated FGFR3 phosphorylates PLCG1
(inferredTo)	[Reaction:R-HSA-5654224] Activated FGFR3 binds PLCG1