Reactome | HIPK2 phosphorylates RUNX1

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HIPK2 phosphorylates RUNX1 Show undefined attributes

catalystActivity	[CatalystActivity:10727156] protein serine/threonine kinase activity of HIPK2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10727160
displayName	HIPK2 phosphorylates RUNX1
eventOf	[Pathway:R-DME-8939243] RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known - Drosophila melanogaster
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8878054] HIPK2 phosphorylates RUNX1 - Homo sapiens
input	3 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-DME-8865330] RUNX1:CBFB [nucleoplasm]
isInDisease	false
isInferred	true
name	HIPK2 phosphorylates RUNX1
output	3 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-DME-8878069] p-S249,S273,S276-RUNX1:CBFB [nucleoplasm]
precedingEvent	[Reaction:R-DME-8865320] CBFB binds RUNX1 - Drosophila melanogaster
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-8878054
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-8939243] RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
(inferredTo)	[Reaction:R-HSA-8878054] HIPK2 phosphorylates RUNX1