Reactome | ATM phosphorylates EYA1-4

Schema > Reaction > Entries

ATM phosphorylates EYA1-4 Show undefined attributes

catalystActivity	[CatalystActivity:10712720] protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10712722
displayName	ATM phosphorylates EYA1-4
eventOf	[Pathway:R-DME-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Drosophila melanogaster
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-DME-5683967] EYA1-4 dephosphorylates tyrosine Y142 of H2AFX - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-5683964] ATM phosphorylates EYA1-4 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [CandidateSet:R-DME-5683966] EYA1-4 [nucleoplasm]
isInDisease	false
isInferred	true
name	ATM phosphorylates EYA1-4
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [CandidateSet:R-DME-5683980] p-EYA1-4 [nucleoplasm]
precedingEvent	[Reaction:R-DME-5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs - Drosophila melanogaster
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5683964
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
(precedingEvent)	[Reaction:R-DME-5683967] EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
(inferredTo)	[Reaction:R-HSA-5683964] ATM phosphorylates EYA1-4