Reactome | CLK:CYC heterodimer binds to cwo gene and activates transcription

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CLK:CYC heterodimer binds to cwo gene and activates transcription Show undefined attributes

authored	[InstanceEdit:432420] Williams, MG, 2009-08-13
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:432644] Williams, MG, 2009-08-14
dbId	432520
displayName	CLK:CYC heterodimer binds to cwo gene and activates transcription
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
eventOf	[Pathway:R-DME-432408] Transcription regulation of cwo gene - Drosophila melanogaster
figure	[Figure:882006] /figures/DrosCircClockC41.jpg
followingEvent	[Reaction:R-DME-432487] CWO binds to cwo gene and represses transcription - Drosophila melanogaster
input	[Complex:R-DME-432591] CLK:CYC [nucleoplasm] [OtherEntity:R-ALL-29428] DNA [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:432653] The clockwork orange Drosophila protein functions as both an activator and a repressor of clock gene expression [LiteratureReference:432628] A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock [LiteratureReference:538804] Clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila [LiteratureReference:538877] Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CLK:CYC heterodimer binds to cwo gene and activates transcription
output	[Complex:R-DME-881986] DNA:CLK:CYC [nucleoplasm]
precedingEvent	[Reaction:R-DME-432516] CLK and CYC bind to form a heterodimer - Drosophila melanogaster [Reaction:R-DME-432537] PP2A dephosphorylates phosphorylated CLK - Drosophila melanogaster
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:909536] Edery, I, 2010-07-06
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-432520
summation	[Summation:432531] The Clock (CLK):Cycle (CYC) heteodimer binds the E-box regul...

Referrals

(hasEvent)	[Pathway:R-DME-432408] Transcription regulation of cwo gene
(precedingEvent)	[Reaction:R-DME-432487] CWO binds to cwo gene and represses transcription

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