Reactome | HS-GAG degradation

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HS-GAG degradation Show undefined attributes

created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10739030
displayName	HS-GAG degradation
eventOf	[Pathway:R-DME-1638091] Heparan sulfate/heparin (HS-GAG) metabolism - Drosophila melanogaster
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:21602] heparan sulfate proteoglycan catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-DME-2024084] HS-GAGs translocate to the lysosome for degradation - Drosophila melanogaster [Reaction:R-DME-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) - Drosophila melanogaster [Reaction:R-DME-1678694] Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans - Drosophila melanogaster [Reaction:R-DME-1678716] IDUA hydrolyses Heparan sulfate chain(1) - Drosophila melanogaster [Reaction:R-DME-1678708] SGSH hydrolyses Heparan sulfate chain(2) - Drosophila melanogaster [Reaction:R-DME-1678660] HGSNAT oligomer acetylates Heparan sulfate chain(3) - Drosophila melanogaster [Reaction:R-DME-1678742] NAGLU hydrolyses Heparan sulfate chain(4) - Drosophila melanogaster [Reaction:R-DME-1678650] IDS hydrolyses Heparan sulfate chain(5) - Drosophila melanogaster [Reaction:R-DME-2090037] IDUA hydrolyses Heparan sulfate chain(6) - Drosophila melanogaster [Reaction:R-DME-2090043] SGSH hydrolyses Heparan sulfate chain(7) - Drosophila melanogaster [Reaction:R-DME-2090085] HGSNAT oligomer acetylates Heparan chain(1) - Drosophila melanogaster [Reaction:R-DME-2090038] NAGLU hydrolyses heparan chain(2) - Drosophila melanogaster [Reaction:R-DME-1678854] GUSB tetramer hydrolyses CS/HS precursor - Drosophila melanogaster [Reaction:R-DME-2090079] GLB1 hydrolyses linker chain(2) - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-2024096] HS-GAG degradation - Homo sapiens
isInDisease	false
isInferred	true
name	HS-GAG degradation
releaseDate	2024-03-27
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-2024096
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-1638091] Heparan sulfate/heparin (HS-GAG) metabolism
(inferredTo)	[Pathway:R-HSA-2024096] HS-GAG degradation

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