Reactome | PIP3 recruits PDK1 and AKT to the membrane

Schema > Reaction > Entries

PIP3 recruits PDK1 and AKT to the membrane Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10818988] Wright, Adam, 2024-03-08
dbId	10865126
displayName	PIP3 recruits PDK1 and AKT to the membrane
eventOf	[Pathway:R-DDI-392451] G beta:gamma signalling through PI3Kgamma - Dictyostelium discoideum
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9603279] PIP3 recruits PDK1 and AKT to the membrane - Homo sapiens
input	[CandidateSet:R-DDI-202088] AKT [cytosol] [EntityWithAccessionedSequence:R-DDI-202210] PDPK1 [cytosol] 2 × [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isInDisease	false
isInferred	true
name	PIP3 recruits PDK1 and AKT to the membrane
output	[Complex:R-DDI-198360] PDK1:AKT:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-DDI-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Dictyostelium discoideum [Reaction:R-DDI-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Dictyostelium discoideum
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-9603279
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-392451] G beta:gamma signalling through PI3Kgamma
(inferredTo)	[Reaction:R-HSA-9603279] PIP3 recruits PDK1 and AKT to the membrane

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