Reactome | Phosphorylation of Cdc25C at Ser216 by CHEK2

Schema > Reaction > Entries

Phosphorylation of Cdc25C at Ser216 by CHEK2 Show undefined attributes

catalystActivity	[CatalystActivity:10820039] protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10818988] Wright, Adam, 2024-03-08
dbId	10823338
displayName	Phosphorylation of Cdc25C at Ser216 by CHEK2
eventOf	[Pathway:R-DDI-75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex - Dictyostelium discoideum
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-DDI-9029987] p-S216-CDC25C translocates to the cytosol - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-DDI-69741] cdc25 [nucleoplasm]
isInDisease	false
isInferred	true
name	Phosphorylation of Cdc25C at Ser216 by CHEK2
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-DDI-156496] phospho-cdc25 [nucleoplasm]
precedingEvent	[Reaction:R-DDI-5683792] p-T68-CHEK2 autophosphorylates - Dictyostelium discoideum
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-75809
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
(precedingEvent)	[BlackBoxEvent:R-DDI-9029987] p-S216-CDC25C translocates to the cytosol
(inferredTo)	[Reaction:R-HSA-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2