Reactome | (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA

Schema > Reaction > Entries

(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10827988] 3-hydroxyacyl-CoA dehydrogenase activity of HSD17B4 dimer [peroxisomal matrix]
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:10818988] Wright, Adam, 2024-03-08
dbId	10827990
displayName	(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA
eventOf	[Pathway:R-DDI-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Dictyostelium discoideum
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-193455] (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-193422] (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA [peroxisomal matrix] [SimpleEntity:R-ALL-192307] NAD+ [peroxisomal matrix]
isInDisease	false
isInferred	true
name	(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA + NAD+ => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + NADH + H+
output	[SimpleEntity:R-ALL-192339] 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA [peroxisomal matrix] [SimpleEntity:R-ALL-193465] H+ [peroxisomal matrix] [SimpleEntity:R-ALL-192305] NADH [peroxisomal matrix]
precedingEvent	[Reaction:R-DDI-192331] 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA - Dictyostelium discoideum
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-193455
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(inferredTo)	[Reaction:R-HSA-193455] (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA

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