Reactome | EP300 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

EP300 [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:10157949] histone acetyltransferase activity of EP300 [nucleoplasm] [CatalystActivity:10195996] peptide-lysine-N-acetyltransferase activity of EP300 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-CFA-9029520] EP300:NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] - Canis familiaris [Complex:R-CFA-3215194] ING2:EP300:p-S15,S20-TP53 Tetramer [nucleoplasm] - Canis familiaris [Complex:R-CFA-1234099] HIF:CBP:p300 [nucleoplasm] - Canis familiaris [Complex:R-CFA-1604462] NOTCH1 Coactivator Complex [nucleoplasm] - Canis familiaris [Complex:R-CFA-9009369] CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] - Canis familiaris [Complex:R-CFA-9023842] CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1 [nucleoplasm] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-9029561] NCOA1 recruits EP300 to the ABCA1 promoter - Canis familiaris [Reaction:R-CFA-6804229] JMY, TTC5 and EP300 bind - Canis familiaris [Reaction:R-CFA-9008271] CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter - Canis familiaris [Reaction:R-CFA-6811479] ING2 recruits EP300 to TP53 - Canis familiaris [Reaction:R-CFA-3222093] BRD7 binds TP53 and EP300 - Canis familiaris [Reaction:R-CFA-8951951] RUNX3 binds EP300 - Canis familiaris [Reaction:R-CFA-8878056] RUNX1:CBFB binds EP300 - Canis familiaris [Reaction:R-CFA-5250930] B-WICH recruits histone acetyltransferases - Canis familiaris [Reaction:R-CFA-9011981] EP300 is recruited to MYC and BCL2 genes - Canis familiaris [Reaction:R-CFA-9023884] NCOA1 recruits EP300 to TGFA promoter - Canis familiaris [Reaction:R-CFA-9008285] NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 - Canis familiaris [Reaction:R-CFA-9038052] GREB1 binds ESR1:ESTG and co-activators - Canis familiaris [BlackBoxEvent:R-CFA-1234167] Formation of HIF:CBP:p300 complex at promoters - Canis familiaris [Reaction:R-CFA-8864307] TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP - Canis familiaris [Reaction:R-CFA-9018499] ESR1:ESTG and EP300 are recruited to TFF3 promoter - Canis familiaris [Reaction:R-CFA-9009371] Binding of AP1 transcriptional activator complexes to CCND1 promoter - Canis familiaris [Reaction:R-CFA-9023840] HATs and coactivators are recruited to the CTSD gene - Canis familiaris
created	[InstanceEdit:10098795] Wright, Adam, 2024-03-07
dbId	10138534
displayName	EP300 [nucleoplasm]
endCoordinate	2414
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-381325] EP300 [nucleoplasm] - Homo sapiens
memberOf	[DefinedSet:R-CFA-1027362] CREBBP,EP300 [nucleoplasm] - Canis familiaris [DefinedSet:R-CFA-9023862] histone acetyltransferases [nucleoplasm] - Canis familiaris
name	EP300 EP300 A0A8I3P730
negativelyRegulates	[NegativeRegulation:10189406] Negative regulation by 'EP300 [nucleoplasm]'
producedByEvent	[Reaction:R-CFA-8952058] CCND1 binds RUNX3 and displaces EP300 - Canis familiaris
referenceEntity	[ReferenceGeneProduct:10138532] UniProt:A0A8I3P730
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49646] Canis familiaris
stId	R-CFA-381325
startCoordinate	2

Referrals

(hasComponent)	[Complex:R-CFA-9029520] EP300:NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] [Complex:R-CFA-9009369] CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] [Complex:R-CFA-1604462] NOTCH1 Coactivator Complex [nucleoplasm] [Complex:R-CFA-1234099] HIF:CBP:p300 [nucleoplasm] [Complex:R-CFA-6804233] p-S203,S221-TTC5:EP300:JMY [nucleoplasm] [Complex:R-CFA-3215194] ING2:EP300:p-S15,S20-TP53 Tetramer [nucleoplasm] [Complex:R-CFA-6811488] ING2:EP300:Ac-K382,p-S15,S20-TP53 Tetramer [nucleoplasm] [Complex:R-CFA-3222096] BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] [Complex:R-CFA-5628870] BRD7:Ac-K382,p-S15,S20-TP53:EP300 [nucleoplasm] [Complex:R-CFA-8864321] TFAP2 homo- and heterodimers:CITED2,CITED4,(CITED1):EP300:CREBBP [nucleoplasm] [Complex:R-CFA-8951959] Ac-K94,K171-RUNX3:CBFB:EP300 [nucleoplasm] [Complex:R-CFA-8951952] RUNX3:CBFB:EP300 [nucleoplasm] [Complex:R-CFA-8936477] RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] [Complex:R-CFA-8878064] RUNX1:CBFB:EP300 [nucleoplasm] [Complex:R-CFA-5250942] B-WICH:rDNA Promoter:KAT2B:KAT2A:EP300 [nucleoplasm] [Complex:R-CFA-8869505] MYSM1:EP300:KAT2B [nucleoplasm] [Complex:R-CFA-9011897] MYC gene, BCL2 gene:HIST1H2AC nucleosome:ESR1:ESTG:EP300 [nucleoplasm] [Complex:R-CFA-9023880] ESR1:estrogen:TFGA gene:NCOA1:EP300 [nucleoplasm] [Complex:R-CFA-9008249] CITED1:EP300:ESR1:estrogen:TGFA gene promoter [nucleoplasm] [Complex:R-CFA-9018479] TFF3 gene:FOXA1:GATA3:ESR1:ESTG:EP300 [nucleoplasm] [Complex:R-CFA-9008268] ESR1:estrogen:ERE:NCOA3:EP300 [nucleoplasm] [Complex:R-CFA-9023842] CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1 [nucleoplasm] [Complex:R-CFA-9038050] GREB1:ESR1:ESTG:EP300:CREBBP [nucleoplasm]
(input)	[Reaction:R-CFA-9029561] NCOA1 recruits EP300 to the ABCA1 promoter [Reaction:R-CFA-9038052] GREB1 binds ESR1:ESTG and co-activators [Reaction:R-CFA-9009371] Binding of AP1 transcriptional activator complexes to CCND1 promoter [BlackBoxEvent:R-CFA-1234167] Formation of HIF:CBP:p300 complex at promoters [Reaction:R-CFA-6804229] JMY, TTC5 and EP300 bind [Reaction:R-CFA-6811479] ING2 recruits EP300 to TP53 [Reaction:R-CFA-3222093] BRD7 binds TP53 and EP300 [Reaction:R-CFA-8864307] TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP [Reaction:R-CFA-8951951] RUNX3 binds EP300 [Reaction:R-CFA-8878056] RUNX1:CBFB binds EP300 [Reaction:R-CFA-5250930] B-WICH recruits histone acetyltransferases [Reaction:R-CFA-9011981] EP300 is recruited to MYC and BCL2 genes [Reaction:R-CFA-9023884] NCOA1 recruits EP300 to TGFA promoter [Reaction:R-CFA-9008271] CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter [Reaction:R-CFA-9018499] ESR1:ESTG and EP300 are recruited to TFF3 promoter [Reaction:R-CFA-9008285] NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 [Reaction:R-CFA-9023840] HATs and coactivators are recruited to the CTSD gene
(output)	[Reaction:R-CFA-8952058] CCND1 binds RUNX3 and displaces EP300
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-381325] EP300 [nucleoplasm]
(hasMember)	[DefinedSet:R-CFA-9023862] histone acetyltransferases [nucleoplasm] [DefinedSet:R-CFA-1027362] CREBBP,EP300 [nucleoplasm]
(activeUnit)	[CatalystActivity:10180364] peptide-lysine-N-acetyltransferase activity of ING2:EP300:p-S15,S20-TP53 Tetramer [nucleoplasm] [CatalystActivity:10165388] acetyltransferase activity of BRD7:p-S15,S20-TP53:EP300 [nucleoplasm]
(physicalEntity)	[CatalystActivity:10157949] histone acetyltransferase activity of EP300 [nucleoplasm] [CatalystActivity:10195996] peptide-lysine-N-acetyltransferase activity of EP300 [nucleoplasm]
(hasCandidate)	[CandidateSet:R-CFA-9620507] KAT2B,(EP300) [nucleoplasm]
(regulator)	[NegativeRegulation:10189406] Negative regulation by 'EP300 [nucleoplasm]'

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