Reactome | Phosphorylation of MDM4 by CHEK2

Schema > Reaction > Entries

Phosphorylation of MDM4 by CHEK2 Show undefined attributes

catalystActivity	[CatalystActivity:10099903] protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10098795] Wright, Adam, 2024-03-07
dbId	10121165
displayName	Phosphorylation of MDM4 by CHEK2
eventOf	[Pathway:R-CFA-69541] Stabilization of p53 - Canis familiaris [Pathway:R-CFA-6804757] Regulation of TP53 Degradation - Canis familiaris
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-6804724] MDM2 ubiquitinates phosphorylated MDM4 - Canis familiaris
inferredFrom	[Reaction:R-HSA-349426] Phosphorylation of MDM4 by CHEK2 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-CFA-6804939] p-S166,S188-MDM2:p-S403-MDM4 [nucleoplasm]
isInDisease	false
isInferred	true
name	Phosphorylation of MDM4 by CHEK2
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-CFA-6804936] p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm]
precedingEvent	[Reaction:R-CFA-349455] Phosphorylation of MDM4 by ATM - Canis familiaris [Reaction:R-CFA-5683792] p-T68-CHEK2 autophosphorylates - Canis familiaris
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-349426
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-6804757] Regulation of TP53 Degradation [Pathway:R-CFA-69541] Stabilization of p53
(precedingEvent)	[Reaction:R-CFA-6804724] MDM2 ubiquitinates phosphorylated MDM4
(inferredTo)	[Reaction:R-HSA-349426] Phosphorylation of MDM4 by CHEK2