Reactome | RAPGEF1 activates RAP1

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RAPGEF1 activates RAP1 Show undefined attributes

catalystActivity	[CatalystActivity:10807420] guanyl-nucleotide exchange factor activity of HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
dbId	10807422
displayName	RAPGEF1 activates RAP1
eventOf	[Pathway:R-CEL-8875555] MET activates RAP1 and RAC1 - Caenorhabditis elegans
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8875568] RAPGEF1 activates RAP1 - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-CEL-354074] RAP1:GDP [plasma membrane]
isInDisease	false
isInferred	true
name	RAPGEF1 activates RAP1
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-CEL-354126] RAP1:GTP [plasma membrane]
precedingEvent	[Reaction:R-CEL-8875558] RAPGEF1 binds CRK,CRKL - Caenorhabditis elegans
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-8875568
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-8875555] MET activates RAP1 and RAC1
(inferredTo)	[Reaction:R-HSA-8875568] RAPGEF1 activates RAP1