Reactome | HSPA8-mediated ATP hydrolysis promotes vesicle uncoating

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HSPA8-mediated ATP hydrolysis promotes vesicle uncoating Show undefined attributes

catalystActivity	[CatalystActivity:10806631] ATP hydrolysis activity of PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane]
category	transition
compartment	[Compartment:24339] clathrin-coated endocytic vesicle membrane
created	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
dbId	10806633
displayName	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
eventOf	[Pathway:R-CEL-8856828] Clathrin-mediated endocytosis - Caenorhabditis elegans
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-8871194] RAB5 and GAPVD1 bind AP-2 - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-CEL-8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane]
isInDisease	false
isInferred	true
name	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
output	[Complex:R-CEL-8868617] clathrin:HSPA8:ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [Complex:R-CEL-8868620] PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane]
precedingEvent	[Reaction:R-CEL-8868660] Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle - Caenorhabditis elegans
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-8868658
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-8856828] Clathrin-mediated endocytosis
(precedingEvent)	[Reaction:R-CEL-8871194] RAB5 and GAPVD1 bind AP-2
(inferredTo)	[Reaction:R-HSA-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating