Reactome | acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]

Schema > Reaction > Entries

acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] Show undefined attributes

catalystActivity	[CatalystActivity:10742782] acetate-CoA ligase activity of ACSS2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
dbId	10742784
displayName	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]
eventOf	[Pathway:R-CEL-71384] Ethanol oxidation - Caenorhabditis elegans
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29416] CH3COO- [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
isInDisease	false
isInferred	true
name	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]
output	[SimpleEntity:R-ALL-76183] Ac-CoA [cytosol] [SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-CEL-71691] acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] - Caenorhabditis elegans
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-71735
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-71384] Ethanol oxidation
(precedingEvent)	[Reaction:R-CEL-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate
(inferredTo)	[Reaction:R-HSA-71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]

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