Reactome | Protein Kinase B (AKT) phosphorylates KSRP

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Protein Kinase B (AKT) phosphorylates KSRP Show undefined attributes

catalystActivity	[CatalystActivity:10765492] protein serine/threonine kinase activity of p-T308,S473-AKT1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
dbId	10765513
displayName	Protein Kinase B (AKT) phosphorylates KSRP
eventOf	[Pathway:R-CEL-450604] KSRP (KHSRP) binds and destabilizes mRNA - Caenorhabditis elegans
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-CEL-450620] p-S193-KSRP binds 14-3-3zeta in the nucleus - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-450499] Protein Kinase B (AKT) phosphorylates KSRP - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-CEL-450485-6] Homologues of KSRP [cytosol]
isInDisease	false
isInferred	true
name	Protein Kinase B (AKT) phosphorylates KSRP
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-CEL-450505-6] Homologues of p-S193-KHSRP [cytosol]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-450499
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-450604] KSRP (KHSRP) binds and destabilizes mRNA
(precedingEvent)	[BlackBoxEvent:R-CEL-450620] p-S193-KSRP binds 14-3-3zeta in the nucleus
(inferredTo)	[Reaction:R-HSA-450499] Protein Kinase B (AKT) phosphorylates KSRP