Reactome | UBE2M [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-BTA-8951749] AcM-UBE2M:NEDD8-UBA3:NAE1:NEDD8 [cytosol] - Bos taurus
consumedByEvent	[Reaction:R-BTA-8951751] Doubly neddylated UBA3:NAE1 binds AcM-UBE2M - Bos taurus
created	[InstanceEdit:10203599] Wright, Adam, 2024-03-07
dbId	10267643
displayName	UBE2M [cytosol]
endCoordinate	183
hasModifiedResidue	[ModifiedResidue:10267637] N-acetyl-L-methionine at 1 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-8951627] AcM-UBE2M [cytosol] - Homo sapiens
name	UBE2M AcM-UBE2M A3KN22
producedByEvent	[Reaction:R-BTA-8952618] AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex - Bos taurus [Reaction:R-BTA-8956025] AcM-UBE2M transfers NEDD8 to CUL9:RBX1 - Bos taurus [Reaction:R-BTA-8952631] AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex - Bos taurus [Reaction:R-BTA-8952626] AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex - Bos taurus [Reaction:R-BTA-4332236] CBL neddylates TGFBR2 - Bos taurus
referenceEntity	[ReferenceGeneProduct:10244909] UniProt:A3KN22
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48898] Bos taurus
stId	R-BTA-8951627
startCoordinate	1

(output)	[Reaction:R-BTA-8952618] AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex [Reaction:R-BTA-8956025] AcM-UBE2M transfers NEDD8 to CUL9:RBX1 [Reaction:R-BTA-8952631] AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex [Reaction:R-BTA-8952626] AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex [Reaction:R-BTA-4332236] CBL neddylates TGFBR2
(activeUnit)	[CatalystActivity:10300670] NEDD8 transferase activity of NEDD8-AcM-UBE2M:CUL9:RBX1 [cytosol] [CatalystActivity:10299288] NEDD8 transferase activity of AcM-UBE2M:NEDD8-UBA3:NAE1:NEDD8 [cytosol]
(input)	[Reaction:R-BTA-8951751] Doubly neddylated UBA3:NAE1 binds AcM-UBE2M
(hasComponent)	[Complex:R-BTA-8951749] AcM-UBE2M:NEDD8-UBA3:NAE1:NEDD8 [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-8951627] AcM-UBE2M [cytosol]