Reactome | Phosphorylation of JAK2

Schema > Reaction > Entries

Phosphorylation of JAK2 Show undefined attributes

catalystActivity	[CatalystActivity:10240117] protein tyrosine kinase activity of IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10203599] Wright, Adam, 2024-03-07
dbId	10240119
displayName	Phosphorylation of JAK2
eventOf	[Pathway:R-BTA-877300] Interferon gamma signaling - Bos taurus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-877269] SOCS-1 and SOCS-3 binds to p-JAK2 - Bos taurus [Reaction:R-BTA-873918] Transphosphorylation of JAK1 - Bos taurus
inferredFrom	[Reaction:R-HSA-873919] Phosphorylation of JAK2 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-BTA-873829] IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane]
isInDisease	false
isInferred	true
name	Phosphorylation of JAK2
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-BTA-873811] IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane]
precedingEvent	[Reaction:R-BTA-873926] IFNG dimer binds IFNGR - Bos taurus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-873919
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-877300] Interferon gamma signaling
(precedingEvent)	[Reaction:R-BTA-877269] SOCS-1 and SOCS-3 binds to p-JAK2 [Reaction:R-BTA-873918] Transphosphorylation of JAK1
(inferredTo)	[Reaction:R-HSA-873919] Phosphorylation of JAK2