Reactome | PTPN11 binds p-7Y-RUNX1

Schema > Reaction > Entries

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9962241
displayName	PTPN11 binds p-7Y-RUNX1
eventOf	[Pathway:R-MMU-8934593] Regulation of RUNX1 Expression and Activity - Mus musculus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-8937767] PTPN11 dephosphorylates RUNX1 - Mus musculus
inferredFrom	[Reaction:R-HSA-8937744] PTPN11 binds p-7Y-RUNX1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-8937712] phospho-p-7Y-RUNX1 [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-8937745] PTPN11 [nucleoplasm]
isInDisease	false
isInferred	true
name	PTPN11 binds p-7Y-RUNX1
output	[Complex:R-MMU-8937751] p-7Y-RUNX1:PTPN11 [nucleoplasm]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8937744
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-8934593] Regulation of RUNX1 Expression and Activity
(precedingEvent)	[Reaction:R-MMU-8937767] PTPN11 dephosphorylates RUNX1
(inferredTo)	[Reaction:R-HSA-8937744] PTPN11 binds p-7Y-RUNX1