Reactome | ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm]

Schema > Complex > Entries

ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:9941994] protein serine/threonine kinase activity of ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-MMU-5684887] Activation of CHEK1 at resected DNA DSBs - Mus musculus
created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9941991
displayName	ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm]
hasComponent	[Complex:R-MMU-5685178] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-113826] CHEK1 [nucleoplasm] [DefinedSet:R-MMU-5685980] EXO1,DNA2:BLM,WRN [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-176296] phospho-Clspn [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-5687710] phospho-p-S990,Ac-K1249-BRIP1 [nucleoplasm] [Complex:R-MMU-176353] RAD17:RFC [nucleoplasm] [Complex:R-MMU-176312] RAD9:HUS1:RAD1 [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-5684880] Rhno1 [nucleoplasm] [Complex:R-MMU-5684985] TIMELESS:TIPIN [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-5684878] Topbp1 [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-5684883] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] - Homo sapiens
name	ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1
producedByEvent	[Reaction:R-MMU-5684882] CHEK1 is recruited to resected DNA DSBs - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-5684883
summation	[Summation:9864367] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-MMU-5684887] Activation of CHEK1 at resected DNA DSBs
(physicalEntity)	[CatalystActivity:9941994] protein serine/threonine kinase activity of ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm]
(output)	[Reaction:R-MMU-5684882] CHEK1 is recruited to resected DNA DSBs
(inferredTo)	[Complex:R-HSA-5684883] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm]

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