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Entries
PKR dimer autophosphorylates
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authored
[InstanceEdit:9833724] Stephan, Ralf, 2023-05-03
catalystActivity
[CatalystActivity:9833965] protein kinase activity of EIF2AK2 dimer [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:9833827] Stephan, Ralf, 2023-05-04
dbId
9833820
displayName
PKR dimer autophosphorylates
edited
[InstanceEdit:9841954] Stephan, Ralf, 2023-08-16
eventOf
[Pathway:R-HSA-9833482] PKR-mediated signaling - Homo sapiens
followingEvent
[Reaction:R-HSA-9835885] p-PKR dimer phosphorylates eIF2-alpha - Homo sapiens
[Reaction:R-HSA-9836515] p-PKR dimer phosphorylates PTPN2 - Homo sapiens
[Reaction:R-HSA-9836322] p-PKR dimer phosphorylates MKK6 - Homo sapiens
[Reaction:R-HSA-9835940] HCMV TRS1 binds PKR dimer - Homo sapiens
[Reaction:R-HSA-9836664] p-PKR dimer phosphorylates PPP2R5A - Homo sapiens
[BlackBoxEvent:R-HSA-9836159] p-PKR dimer phosphorylates DHX9 - Homo sapiens
[Reaction:R-HSA-9836404] p-PKR dimer phosphorylates MAPT - Homo sapiens
[Reaction:R-HSA-9836362] p-PKR dimer phosphorylates TP53 tetramer - Homo sapiens
[Reaction:R-HSA-9836184] p-PKR dimer phosphorylates CDK1 - Homo sapiens
[Reaction:R-HSA-9836383] p-PKR dimer phosphorylates ILF3:ILF2 - Homo sapiens
[Reaction:R-HSA-9836435] p-PKR dimer phosphorylates SNCA - Homo sapiens
input
22 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-9833725] EIF2AK2 dimer [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9633785] Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2
[LiteratureReference:9833846] Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase
[LiteratureReference:9833737] Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop
[LiteratureReference:9833767] Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon
[LiteratureReference:9833728] Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition
[LiteratureReference:9833841] Auto-phosphorylation Represses Protein Kinase R Activity
[LiteratureReference:9833844] PKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs
[LiteratureReference:9833822] Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR
[LiteratureReference:9833829] Hepatitis C virus envelope protein E2 does not inhibit PKR by simple competition with autophosphorylation sites in the RNA-binding domain
[LiteratureReference:9835110] Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR
modified
[InstanceEdit:9841952] Stephan, Ralf, 2023-08-16
name
PKR dimer autophosphorylates
output
22 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-9833821] p-EIF2AK2 dimer [cytosol]
precedingEvent
[Reaction:R-HSA-9833723] PKR forms a dimer - Homo sapiens
regulatedBy
[NegativeRegulation:9835897] Negative regulation by 'TRS1 [cytosol]'
regulationReference
[RegulationReference:9835887] Negative regulation by 'TRS1 [cytosol]' Mechanism of Protein Kinase R Inhibition by Human Cytomegalovirus pTRS1
relatedSpecies
[Species:2671791] Human cytomegalovirus
releaseDate
2023-09-23
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9841953] Patel, Rekha C, 2023-08-16
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9833820
summation
[Summation:9833964] Control of protein translation via phosphorylation of eIF-2a...
Referrals
(precedingEvent)
[Reaction:R-HSA-9835885] p-PKR dimer phosphorylates eIF2-alpha
[Reaction:R-HSA-9836515] p-PKR dimer phosphorylates PTPN2
[Reaction:R-HSA-9836322] p-PKR dimer phosphorylates MKK6
[Reaction:R-HSA-9835940] HCMV TRS1 binds PKR dimer
[Reaction:R-HSA-9836664] p-PKR dimer phosphorylates PPP2R5A
[BlackBoxEvent:R-HSA-9836159] p-PKR dimer phosphorylates DHX9
[Reaction:R-HSA-9836404] p-PKR dimer phosphorylates MAPT
[Reaction:R-HSA-9836362] p-PKR dimer phosphorylates TP53 tetramer
[Reaction:R-HSA-9836184] p-PKR dimer phosphorylates CDK1
[Reaction:R-HSA-9836383] p-PKR dimer phosphorylates ILF3:ILF2
[Reaction:R-HSA-9836435] p-PKR dimer phosphorylates SNCA
(hasEvent)
[Pathway:R-HSA-9833482] PKR-mediated signaling
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