UniProt:O43929 ORC4

chain
  • chain:1-436
checksum A7020B6690E30B4E
comment
  • FUNCTION Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.SUBUNIT Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (PubMed:12909626, PubMed:17716973). Interacts with DBF4 (By similarity). Interacts with POLQ (PubMed:24989122).SIMILARITY Belongs to the ORC4 family.
crossReference
databaseName UniProt
dbId 97399
description
  • recommendedName: Origin recognition complex subunit 4
displayName UniProt:O43929 ORC4
geneName
  • ORC4
  • ORC4L
identifier O43929
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • ATP-binding
  • Disease variant
  • DNA replication
  • DNA-binding
  • Dwarfism
  • Methylation
  • Nucleotide-binding
  • Nucleus
  • Reference proteome
modified [InstanceEdit:11703169] Weiser, JD, 2021-09-15
name
  • ORC4
otherIdentifier
  • 0004210372
  • 11730783_a_at
  • 11730784_x_at
  • 11744978_a_at
  • 16903427
  • 203351_s_at
  • 203352_at
  • 2580297
  • 2580299
  • 2580301
  • 2580302
  • 2580303
  • 2580305
  • 2580306
  • 2580307
  • 2580308
  • 2580312
  • 2580313
  • 2580315
  • 2580316
  • 2580319
  • 2580320
  • 2580323
  • 2580325
  • 2580327
  • 2580329
  • 2580330
  • 2580334
  • 2580335
  • 2580336
  • 2580337
  • 2580339
  • 2580343
  • 2580344
  • 2580345
  • 36481_at
  • 5000
  • 8055645
  • A_23_P131149
  • A_32_P141612
  • GE61725
  • GO:0000166
  • GO:0000228
  • GO:0000781
  • GO:0000808
  • GO:0003674
  • GO:0003677
  • GO:0003688
  • GO:0005515
  • GO:0005524
  • GO:0005575
  • GO:0005622
  • GO:0005634
  • GO:0005654
  • GO:0005664
  • GO:0005694
  • GO:0005730
  • GO:0005737
  • GO:0005829
  • GO:0006259
  • GO:0006260
  • GO:0006270
  • GO:0008150
  • GO:0009058
  • GO:0016887
  • GO:0022607
  • GO:0032991
  • GO:0034641
  • GO:0036388
  • GO:0043167
  • GO:0043226
  • GO:0065003
  • HMNXSV003017417
  • ILMN_1740083
  • PH_hs_0025726
  • PH_hs_0036013
  • TC02002408.hg
  • g2906225_3p_a_at
  • g4505522_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ORC4_HUMAN
  • B7Z3D0
  • B7Z5F1
  • D3DP86
  • F5H069
  • Q96C42
sequenceLength 436
species [Species:48887] Homo sapiens
url http://purl.uniprot.org/uniprot/O43929
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