14-3-3 proteins directly shuttle SARS-CoV-1 N protein in a p...

created [InstanceEdit:9729515] Stephan, Ralf, 2021-04-28
dbId 9729510
displayName 14-3-3 proteins directly shuttle SARS-CoV-1 N protein in a p...
modified [InstanceEdit:9765897] Shamovsky, Veronica, 2022-02-17
schemaClass Summation
text 14-3-3 proteins directly shuttle SARS-CoV-1 N protein in a phosphorylation-dependent manner from nucleus to cytosol (Surjit et al, 2005). Polyphosphorylated SARS-CoV-2 N interacts with all seven human 14-3-3 isoforms via its phosphorylated S197. It is probable that this results in the shuttling of phosphorylated N from nucleus to cytosol. Moreover, 14-3-3 binding to p-N may present a cell immune-like response to the viral infection aimed at arresting or neutralizing N activities. On the other hand, in light of the abundance of N protein in the infected cell, p-N may instead arrest 14-3-3 proteins in the cytoplasm and indirectly disrupt cellular processes involving 14-3-3 (Tugaeva et al, 2021).
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