UniProt:Q8TCD5 NT5C

chain
  • chain:1-201
checksum C4C289BBDEC0FA89
comment
  • FUNCTION Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.COFACTOR Homodimer.INTERACTION Detected in skeletal muscle, heart and pancreas.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SIMILARITY Belongs to the 5'(3')-deoxyribonucleotidase family.
crossReference
databaseName UniProt
dbId 96661
description
  • recommendedName: 5'(3')-deoxyribonucleotidase, cytosolic type ecNumber: 3.1.3.- alternativeName: Cytosolic 5',3'-pyrimidine nucleotidase alternativeName: Deoxy-5'-nucleotidase 1 shortName: dNT-1
displayName UniProt:Q8TCD5 NT5C
geneName
  • NT5C
  • DNT1
  • UMPH2
identifier Q8TCD5
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Cytoplasm
  • Direct protein sequencing
  • Hydrolase
  • Magnesium
  • Metal-binding
  • Nucleotide metabolism
  • Nucleotide-binding
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • NT5C
otherIdentifier
  • 11751638_a_at
  • 1557303_PM_at
  • 1557303_at
  • 16848731
  • 219214_3p_s_at
  • 219214_PM_s_at
  • 219214_s_at
  • 30833
  • 3770587
  • 3770589
  • 3770590
  • 3770591
  • 3770592
  • 3770593
  • 3770594
  • 3770595
  • 3770596
  • 3770597
  • 3770598
  • 3770599
  • 3770600
  • 3770601
  • 3770602
  • 3770603
  • 3770604
  • 3770605
  • 54055_at
  • 75120_at
  • 8018297
  • A_23_P66439
  • A_33_P3229256
  • GE54984
  • GE56967
  • GO:0000166
  • GO:0000255
  • GO:0003824
  • GO:0005634
  • GO:0005737
  • GO:0005739
  • GO:0005829
  • GO:0006204
  • GO:0006249
  • GO:0008252
  • GO:0008253
  • GO:0009117
  • GO:0009223
  • GO:0009264
  • GO:0016311
  • GO:0016787
  • GO:0016791
  • GO:0019103
  • GO:0042802
  • GO:0043226
  • GO:0043605
  • GO:0046050
  • GO:0046055
  • GO:0046074
  • GO:0046079
  • GO:0046872
  • GO:0050483
  • GO:0055086
  • GO:0070062
  • GO:1901135
  • HMNXSV003028776
  • Hs2.376383.1.S1_3p_at
  • ILMN_1806432
  • PH_hs_0004068
  • TC17001871.hg
  • g13430849_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • NT5C_HUMAN
  • Q96HS6
  • Q9NP82
sequenceLength 201
species [Species:48887] Homo sapiens
url http://purl.uniprot.org/uniprot/Q8TCD5
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