2'-5'-oligoadenylate synthetase 2 (OAS2) polymerizes ATP into 5'-triphosphorylated, 2'-5'-linked oligoadenylate (2-5A) (Hovanessian AG et al. 1988; Sarkar SN et al. 1999, 2002). 2-5A molecules are recognized by ribonuclease L (RNase L) (Han Y et al. 2014; Huang H et al. 2014). Activated RNase L cleaves viral and cellular RNA resulting in the inhibition of viral replication (Silverman RH 2007).