Based on studies in mice, glucocorticoid receptor (NR3C1) ac...

created [InstanceEdit:9009088] Orlic-Milacic, Marija, 2017-06-15
dbId 9009090
displayName Based on studies in mice, glucocorticoid receptor (NR3C1) ac...
modified [InstanceEdit:9009146] Orlic-Milacic, Marija, 2017-06-15
schemaClass Summation
text Based on studies in mice, glucocorticoid receptor (NR3C1) activated by dexamethasone (DEXA) binds to glucocorticoid receptor response element (GRE) in the proximal (P2) promoter of the RUNX2 gene. NR3C1 may also recruit histone deacetylase HDAC1 to the RUNX2 promoter (Zhang et al. 2012). Similar to the mouse promoter, human RUNX2 P2 promoter also contains GREs.
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