Reactome | CD99 is a glycoprotein found on the leukocytes surface. It h...

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created	[InstanceEdit:8867142] Garapati, Phani Vijay, 2016-04-06
dbId	8867171
displayName	CD99 is a glycoprotein found on the leukocytes surface. It h...
literatureReference	[LiteratureReference:8867257] A T cell surface molecule different from CD2 is involved in spontaneous rosette formation with erythrocytes [LiteratureReference:8867211] A human thymus-leukemia antigen defined by hybridoma monoclonal antibodies [LiteratureReference:8867217] Characterization of a human endocrine tissue and tumor-associated Ewing's sarcoma antigen [LiteratureReference:8867149] The biochemical characterization of E2, a T cell surface molecule involved in rosettes
modified	[InstanceEdit:8939161] Jupe, Steve, 2016-09-16
schemaClass	Summation
text	CD99 is a glycoprotein found on the leukocytes surface. It has been variously described as a human thymus leukemia Ag (Levy et al. 1979), a Ewing's sarcoma-specific membrane marker molecule (Hamilton et al. 1988) and a putative adhesion molecule (termed E2) involved in spontaneous rosette formation of T cells with erythrocytes (Aubrit et al. 1989, Bernard et al. 1988). CD99L2 is a paralog of CD99 that directly interacts with CD99 to form a heterodimer via its cytoplasmic domain. This interaction positively regulates CD99L2 trafficking to cell surfaces (Nam et al. 2013).

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