UniProt:O95639 CPSF4

chain
  • chain:1-269
checksum 49444E3EB840464A
comment
  • FUNCTION Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).SUBUNIT Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Interacts with FIP1L1.SUBUNIT (Microbial infection) Interacts with influenza A virus NS1 blocks processing of pre-mRNAs, thereby preventing nuclear export of host cell mRNAs.INTERACTION May be due to a competing acceptor splice site.SIMILARITY Belongs to the CPSF4/YTH1 family.
crossReference
databaseName UniProt
dbId 88099
description
  • recommendedName: Cleavage and polyadenylation specificity factor subunit 4 alternativeName: Cleavage and polyadenylation specificity factor 30 kDa subunit shortName: CPSF 30 kDa subunit alternativeName: NS1 effector domain-binding protein 1 shortName: Neb-1 alternativeName: No arches homolog
displayName UniProt:O95639 CPSF4
geneName
  • CPSF4
  • CPSF30
  • NAR
  • NEB1
identifier O95639
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Host-virus interaction
  • Metal-binding
  • mRNA processing
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • RNA-binding
  • Zinc
  • Zinc-finger
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • CPSF4
otherIdentifier
  • 10898
  • 11734082_a_at
  • 11739169_a_at
  • 11747753_a_at
  • 206688_PM_s_at
  • 206688_s_at
  • 3014765
  • 3014766
  • 3014771
  • 3014774
  • 3014776
  • 3014778
  • 3014780
  • 3014785
  • 3014786
  • 3014793
  • 3014794
  • 3014795
  • 3014796
  • 3014797
  • 3014798
  • 35743_at
  • 8134599
  • A_14_P100742
  • A_23_P42997
  • GE59454
  • GO:0003676
  • GO:0003677
  • GO:0003723
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005847
  • GO:0006397
  • GO:0008270
  • GO:0016071
  • GO:0043226
  • GO:0043231
  • GO:0046872
  • GO:0098789
  • GO:1990837
  • HMNXSV003004124
  • ILMN_1660426
  • ILMN_2357260
  • PH_hs_0025371
  • TC07000594.hg
  • g5729938_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CPSF4_HUMAN
  • D6W5S8
  • Q6FGE6
  • Q86TF8
  • Q9BTW6
sequenceLength 269
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/O95639
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