UniProt:P42771 CDKN2A

chain
  • chain:1-156
checksum E59C0E6174B48255
comment
  • FUNCTION Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.SUBUNIT Heterodimer with CDK4 or CDK6. Predominant p16 complexes contained CDK6. Interacts with CDK4 (both 'T-172'-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase activity. Interacts with ISCO2.TISSUE SPECIFICITY Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.PTM Phosphorylation seems to increase interaction with CDK4.DISEASE The association between cutaneous and uveal melanomas in some families suggests that mutations in CDKN2A may account for a proportion of uveal melanomas. However, CDKN2A mutations are rarely found in uveal melanoma patients.SIMILARITY Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.CAUTION The proteins described here are encoded by the gene CDKN2A, but are completely unrelated in terms of sequence and function to tumor suppressor ARF (AC Q8N726) which is encoded by the same gene.
crossReference
databaseName UniProt
dbId 87039
description
  • recommendedName: fullName evidence="26"Cyclin-dependent kinase inhibitor 2A alternativeName: Cyclin-dependent kinase 4 inhibitor A shortName:CDK4I alternativeName: Multiple tumor suppressor 1 shortName:MTS-1 alternativeName: p16-INK4a shortName:p16-INK4 shortName:p16INK4A
displayName UniProt:P42771 CDKN2A
geneName
  • CDKN2A
  • CDKN2
  • MTS1
identifier P42771
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • ANK repeat
  • Cell cycle
  • Cytoplasm
  • Disease variant
  • Li-Fraumeni syndrome
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • Tumor suppressor
modified [InstanceEdit:11703684] Shorser, Solomon, 2021-05-28
name
  • CDKN2A
otherIdentifier
  • 0002570204
  • 0005130288
  • 0101400494
  • 1029
  • 11718293_a_at
  • 1713_s_at
  • 207039_at
  • 209644_x_at
  • 211156_at
  • 3201444
  • 3201445
  • 3201446
  • 3201447
  • 3201448
  • 3201450
  • 3201451
  • 3201457
  • 3201458
  • 3201459
  • 3201460
  • 3201461
  • 3201464
  • 3201465
  • 3201466
  • 3201467
  • 3201477
  • 3201478
  • 3201483
  • 3201485
  • 73132_r_at
  • 8160441
  • A_23_P43484
  • A_23_P43490
  • A_33_P3411628
  • GE59038
  • GO:0000082
  • GO:0000278
  • GO:0001953
  • GO:0003674
  • GO:0003723
  • GO:0004861
  • GO:0005515
  • GO:0005575
  • GO:0005622
  • GO:0005634
  • GO:0005694
  • GO:0005737
  • GO:0005829
  • GO:0006464
  • GO:0006950
  • GO:0007049
  • GO:0007050
  • GO:0007155
  • GO:0007165
  • GO:0007265
  • GO:0007568
  • GO:0008134
  • GO:0008150
  • GO:0008219
  • GO:0008283
  • GO:0008285
  • GO:0009058
  • GO:0016301
  • GO:0016310
  • GO:0019899
  • GO:0019901
  • GO:0022607
  • GO:0030234
  • GO:0030308
  • GO:0032088
  • GO:0034393
  • GO:0034641
  • GO:0035985
  • GO:0035986
  • GO:0040007
  • GO:0042326
  • GO:0043226
  • GO:0045736
  • GO:0045892
  • GO:0051059
  • GO:0051276
  • GO:0060260
  • GO:0090398
  • GO:0090399
  • GO:2000111
  • GO:2000134
  • GO:2000774
  • HMNXSV003019577
  • ILMN_1717714
  • ILMN_1757255
  • PH_hs_0019731
  • U26727_at
  • g1353569_3p_a_at
  • g1353569_3p_x_at
  • g4206166_3p_a_at
  • g4502748_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CDN2A_HUMAN
  • A5X2G7
  • D3DRK1
  • G3XAG3
  • O95440
  • Q15191
  • Q5VVJ5
  • Q96B52
  • Q9NP05
sequenceLength 156
species [Species:48887] Homo sapiens
url http://purl.uniprot.org/uniprot/P42771

Referrals

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