created | [InstanceEdit:77247] Gillespie, ME, 2003-09-19 00:00:00 |
dbId | 77311 |
displayName | The third pass through the beta-oxidation spiral picks up wh... |
modified | [InstanceEdit:77397] Gillespie, ME, 2003-10-25 00:00:00 |
schemaClass | Summation |
text | The third pass through the beta-oxidation spiral picks up where the last left off with the saturated fatty acid lauroyl-CoA and produces decanoyl-CoA. Four enzymatic steps are required starting with LCAD CoA dehydrogenase (Long Chain) activity, followed by the enoyl-CoA hydratase activity of crotonase, the 3-hydroxyacyl-CoA dehydrogenase activity of the short chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD), and completed by the ketoacyl-CoA thiolase activity, present in the mitochondrial membrane associated trifunctional protein. Note that the 3-hydroxyacyl-CoA dehydrogenase activity of SCHAD is not actually limited to short chain fatty acids, in fact SCHAD has a broad substrate specificity. |
(summation) |
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