UniProt:P23588 EIF4B

chain
  • chain:1-611
checksum 31CEFEA865FB10D2
comment
  • FUNCTION Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.SUBUNIT Self-associates and interacts with EIF3 p170 subunit.PTM Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex.
crossReference
databaseName UniProt
dbId 72588
description
  • recommendedName: Eukaryotic translation initiation factor 4B shortName:eIF-4B
displayName UniProt:P23588 EIF4B
geneName
  • EIF4B
identifier P23588
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Direct protein sequencing
  • Initiation factor
  • Isopeptide bond
  • Phosphoprotein
  • Protein biosynthesis
  • Reference proteome
  • RNA-binding
  • Ubl conjugation
modified [InstanceEdit:11703169] Weiser, JD, 2021-09-15
name
  • EIF4B
otherIdentifier
  • 0005910184
  • 11747066_x_at
  • 11752470_s_at
  • 11752757_s_at
  • 11752758_x_at
  • 11756144_s_at
  • 16751570
  • 1975
  • 211937_at
  • 211938_at
  • 2639039
  • 2660283
  • 2999321
  • 3017474
  • 3017478
  • 3017482
  • 3017483
  • 3017484
  • 3017486
  • 3017487
  • 3017488
  • 3017489
  • 3017491
  • 3017492
  • 3017493
  • 3017494
  • 3017495
  • 3017496
  • 3180872
  • 3180876
  • 3180877
  • 3180878
  • 3180879
  • 3415625
  • 3415626
  • 3415627
  • 3415631
  • 3415634
  • 3415639
  • 3415640
  • 3415642
  • 3415644
  • 3415645
  • 3415646
  • 3415647
  • 3415648
  • 3415649
  • 3415652
  • 3415654
  • 3415655
  • 3415657
  • 3415658
  • 3415659
  • 3415660
  • 3415661
  • 3415662
  • 39110_at
  • 4018280
  • 4018281
  • 4018282
  • 4018283
  • 4018285
  • 4018286
  • 4018288
  • 4018289
  • 4018291
  • 4018292
  • 4018293
  • 4018294
  • 4018295
  • 4018298
  • 7955646
  • 8135268
  • 87803_s_at
  • A_23_P162679
  • A_24_P218970
  • GE81018
  • GE85788
  • GO:0001731
  • GO:0003674
  • GO:0003676
  • GO:0003723
  • GO:0003743
  • GO:0005515
  • GO:0005575
  • GO:0005622
  • GO:0005737
  • GO:0005829
  • GO:0006412
  • GO:0006413
  • GO:0006446
  • GO:0008135
  • GO:0008150
  • GO:0009058
  • GO:0016281
  • GO:0022607
  • GO:0022618
  • GO:0030425
  • GO:0032991
  • GO:0033592
  • GO:0034057
  • GO:0034641
  • GO:0043024
  • GO:0043025
  • GO:0065003
  • GO:0097010
  • GO:0098794
  • HMNXSV003014771
  • Hs.283330.1.S1_3p_s_at
  • Hs.93379.0.S1_3p_at
  • ILMN_1655497
  • PH_hs_0031414
  • TC12000425.hg
  • X55733_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • IF4B_HUMAN
  • B4DS13
  • Q4G0E3
  • Q53HQ2
  • Q6GPH5
  • Q6IB46
  • Q8WYK5
sequenceLength 611
species [Species:48887] Homo sapiens
url http://purl.uniprot.org/uniprot/P23588
Cite Us!