UniProt:P41091 EIF2S3

chain
  • initiator methionine:
  • chain:2-472
checksum 7A292A6AAF6DF983
comment
  • FUNCTION Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC) (By similarity). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (By similarity). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity).CATALYTIC ACTIVITY GTP + H2O = GDP + H(+) + phosphateSUBUNIT Eukaryotic translation initiation factor 2 eIF2 is a heterotrimeric complex composed of an alpha (EIF2S1), a beta (EIF2S2) and a gamma (EIF2S3) chain (PubMed:23063529, PubMed:31836389, PubMed:35031321, PubMed:31048492). eIF2 is member of the 43S pre-initiation complex (43S PIC) (PubMed:23063529). Interacts (via C-terminus) with CDC123; the interaction is direct (PubMed:35031321, PubMed:37507029).INTERACTION Expressed in testis, brain, liver and muscle.DEVELOPMENTAL STAGE Expressed in the developing endocrine organs.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE Defects in EIF2S3 are the cause of hypopituitarism with glucose dysregulation.MISCELLANEOUS Encoded by an chromosome X-linked gene which escapes inactivation. Does not have any homolog on chromosome Y.SIMILARITY Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
crossReference
databaseName UniProt
dbId 72513
description
  • recommendedName: Eukaryotic translation initiation factor 2 subunit 3 ecNumber evidence="2"3.6.5.3 alternativeName: Eukaryotic translation initiation factor 2 subunit gamma X shortName: eIF2-gamma X shortName: eIF2gX
displayName UniProt:P41091 EIF2S3
geneName
  • EIF2S3
  • EIF2G
identifier P41091
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Cytoplasm
  • Direct protein sequencing
  • Disease variant
  • Epilepsy
  • GTP-binding
  • Hydrolase
  • Initiation factor
  • Intellectual disability
  • Nucleotide-binding
  • Obesity
  • Phosphoprotein
  • Protein biosynthesis
  • Reference proteome
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • EIF2S3
otherIdentifier
  • 11719066_a_at
  • 11719067_s_at
  • 11757858_s_at
  • 11757910_x_at
  • 1272_at
  • 1968
  • 205321_PM_at
  • 205321_at
  • 224935_PM_at
  • 224935_at
  • 224936_PM_at
  • 224936_at
  • 3404722
  • 35934_at
  • 3971879
  • 3971880
  • 3971882
  • 3971883
  • 3971885
  • 3971887
  • 3971888
  • 3971889
  • 3971890
  • 3971891
  • 3971892
  • 3971893
  • 3971899
  • 3971900
  • 3971901
  • 3971902
  • 3971903
  • 44646_r_at
  • 8166493
  • A_23_P137031
  • GE80077
  • GO:0000049
  • GO:0000166
  • GO:0001731
  • GO:0002181
  • GO:0003723
  • GO:0003743
  • GO:0003824
  • GO:0003924
  • GO:0005515
  • GO:0005525
  • GO:0005576
  • GO:0005615
  • GO:0005737
  • GO:0005829
  • GO:0005850
  • GO:0006412
  • GO:0006413
  • GO:0008135
  • GO:0016787
  • GO:0043226
  • GO:0045182
  • GO:0045296
  • GO:0065003
  • GO:0070062
  • HMNXSV003012359
  • Hs.30376.1.A1_3p_at
  • Hs.30376.1.A2_3p_at
  • ILMN_1665717
  • L19161_at
  • PH_hs_0030533
  • TC0X000114.hg
  • TC0X001625.hg
  • g4503506_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • IF2G_HUMAN
  • A0A024RBY4
  • A8K2Y2
  • B2R5N2
  • B5BTZ4
  • Q53HK3
sequenceLength 472
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/P41091
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