UniProt:P41238 APOBEC1

chain
  • chain:1-236
checksum 28466B43F7FD82F7
comment
  • FUNCTION Cytidine deaminase catalyzing the cytidine to uridine postranscriptional editing of a variety of mRNAs (PubMed:30844405). Form complexes with cofactors that confer differential editing activity and selectivity. Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the apolipoprotein B mRNA (PubMed:24916387). Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA (PubMed:11727199). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (By similarity).CATALYTIC ACTIVITY a cytidine in mRNA + H(+) + H2O = a uridine in mRNA + NH4(+)CATALYTIC ACTIVITY cytidine(6666) in apoB mRNA + H(+) + H2O = NH4(+) + uridine(6666) in apoB mRNACOFACTOR Binds 1 Zn(2+) ion per subunit.SUBUNIT Homodimer (PubMed:8078915). Interacts with A1CF; form an mRNA editing complex (PubMed:30844405). Interacts with RBM47; form an mRNA editing complex (PubMed:24916387, PubMed:30844405). Found in a complex with CELF2/CUGBP2 and A1CF. Interacts with HNRPAB (PubMed:8999813). Interacts with SYNCRIP (PubMed:11352648).INTERACTION Expressed exclusively in the small intestine.SIMILARITY Belongs to the cytidine and deoxycytidylate deaminase family.
crossReference
databaseName UniProt
dbId 72288
description
  • recommendedName: fullName evidence="18"C->U-editing enzyme APOBEC-1 ecNumber evidence="5 8"3.5.4.- alternativeName: fullName evidence="19"Apolipoprotein B mRNA-editing enzyme catalytic subunit 1 shortName evidence="14"APO1 shortName evidence="16"APOBEC-1 shortName: Apolipoprotein B mRNA-editing enzyme 1 ecNumber evidence="5"3.5.4.36 alternativeName: fullName evidence="15"HEPR alternativeName: fullName evidence="18"mRNA(cytosine(6666)) deaminase 1
displayName UniProt:P41238 APOBEC1
geneName
  • APOBEC1
identifier P41238
isSequenceChanged false
keyword
  • 3D-structure
  • Cytoplasm
  • Hydrolase
  • Metal-binding
  • mRNA processing
  • Nucleus
  • Reference proteome
  • Zinc
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • APOBEC1
otherIdentifier
  • 11730904_at
  • 16760814
  • 207158_PM_at
  • 207158_at
  • 33573_at
  • 339
  • 3442762
  • 3442763
  • 3442764
  • 3442766
  • 3442767
  • 3442768
  • 3442769
  • 3442770
  • 3442771
  • 7960821
  • A_23_P14019
  • GE60461
  • GO:0003723
  • GO:0003824
  • GO:0004126
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005737
  • GO:0006325
  • GO:0006397
  • GO:0006629
  • GO:0006641
  • GO:0008270
  • GO:0009972
  • GO:0010332
  • GO:0016071
  • GO:0016554
  • GO:0016556
  • GO:0016787
  • GO:0030895
  • GO:0035925
  • GO:0042127
  • GO:0042157
  • GO:0042158
  • GO:0042953
  • GO:0043226
  • GO:0045293
  • GO:0046872
  • GO:0048255
  • GO:0051649
  • GO:0055086
  • GO:0080111
  • GO:0090209
  • GO:0090310
  • GO:0140098
  • GO:1901135
  • GO:1901537
  • GO:2000623
  • HMNXSV003014986
  • ILMN_1813881
  • L26234_at
  • PH_hs_0000066
  • TC12001163.hg
  • g5921993_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ABEC1_HUMAN
  • Q9UE64
  • Q9UM71
sequenceLength 236
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/P41238
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