UniProt:Q15629 TRAM1

chain
  • chain:1-374
checksum 9232ADA33DE20076
comment
  • FUNCTION Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel (PubMed:1315422, PubMed:8616892, PubMed:9506517, PubMed:12475939, PubMed:32013668). Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER (PubMed:9506517). May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport (PubMed:32013668). Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane (PubMed:8616892). Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane (PubMed:12475939). Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome (PubMed:20430023).FUNCTION (Microbial infection) In case of cytomegalovirus infection, participates in US2- and US11-mediated ER-to-cytosol retrotranslocation and subsequent degradation of major histocompatibility complex (MHC) class I heavy chains, thereby decreasing the immune detection by cytotoxic T-cells.SUBUNIT Interacts with SEC61B (PubMed:19121997). May interact with Derlin-1/DERL1 (PubMed:19121997).SUBUNIT (Microbial infection) Interacts with human cytomegalovirus/HHV-5 proteins US2 and US11.INTERACTION Up-regulated upon endoplasmic reticulum stress.PTM N-glycosylated.SIMILARITY Belongs to the TRAM family.
crossReference
databaseName UniProt
dbId 66381
description
  • recommendedName: fullName evidence="13"Translocating chain-associated membrane protein 1 shortName evidence="13"Protein TRAM1
displayName UniProt:Q15629 TRAM1
geneName
  • TRAM1
  • TRAM
identifier Q15629
isSequenceChanged false
keyword
  • Alternative splicing
  • Endoplasmic reticulum
  • Glycoprotein
  • Host-virus interaction
  • Membrane
  • Phosphoprotein
  • Protein transport
  • Reference proteome
  • Translocation
  • Transmembrane
  • Transmembrane helix
  • Transport
  • Unfolded protein response
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • TRAM1
otherIdentifier
  • 11715924_a_at
  • 11715925_a_at
  • 11757983_s_at
  • 17078102
  • 201398_PM_s_at
  • 201398_s_at
  • 201399_PM_s_at
  • 201399_s_at
  • 23471
  • 3139903
  • 3139904
  • 3139905
  • 3139906
  • 3139907
  • 3139908
  • 3139912
  • 3139913
  • 3139915
  • 3139917
  • 3139921
  • 3139925
  • 3139926
  • 3139927
  • 3139928
  • 3139939
  • 3139940
  • 3139941
  • 3139942
  • 3139943
  • 34796_at
  • 8151281
  • A_23_P112135
  • GE59897
  • GO:0005515
  • GO:0005783
  • GO:0005789
  • GO:0006613
  • GO:0006616
  • GO:0006886
  • GO:0006986
  • GO:0015031
  • GO:0016020
  • GO:0038023
  • GO:0043226
  • GO:0045048
  • GO:0055085
  • GO:0060089
  • GO:0061024
  • HMNXSV003040786
  • ILMN_1737146
  • PH_hs_0000455
  • TC08001312.hg
  • X63679_at
  • g12653796_3p_at
  • g7657654_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TRAM1_HUMAN
  • B4E0K2
sequenceLength 374
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/Q15629
Cite Us!