Reactome | UniProt:Q11203 ST3GAL3

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UniProt:Q11203 ST3GAL3 Show undefined attributes

chain	chain:1-375
checksum	C9B7B61AD580EC2E
comment	FUNCTION Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc.CATALYTIC ACTIVITY a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)PATHWAY Protein modification; protein glycosylation.INTERACTION Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.ALTERNATIVE PRODUCTS Highly expressed in adult skeletal muscle and in all fetal tissues examined and to a much lesser extent in placenta, lung and liver.PTM The soluble form derives from the membrane form by proteolytic processing.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SIMILARITY Belongs to the glycosyltransferase 29 family.ONLINE INFORMATION ST3Gal III
crossReference	[DatabaseIdentifier:10979372] Pharos - Targets:Q11203 [DatabaseIdentifier:11066641] OpenTargets:ENSG00000126091 [DatabaseIdentifier:11604106] RefSeq:NP_001257388.1 [DatabaseIdentifier:11604110] RefSeq:NP_001257389.1 [DatabaseIdentifier:11604118] RefSeq:NP_001257390.1 [DatabaseIdentifier:11604122] RefSeq:NP_001257391.1 [DatabaseIdentifier:11604130] RefSeq:NP_001257392.1 [DatabaseIdentifier:11604134] RefSeq:NP_001257393.1 [DatabaseIdentifier:11604135] RefSeq:NP_001257394.1 [DatabaseIdentifier:11604137] RefSeq:NP_001257395.1 [DatabaseIdentifier:11604143] RefSeq:NP_006270.1 [DatabaseIdentifier:11604144] RefSeq:NP_777623.2 [DatabaseIdentifier:11604150] RefSeq:NP_777624.1 [DatabaseIdentifier:11604156] RefSeq:NP_777625.1 [DatabaseIdentifier:11604162] RefSeq:NP_777626.1 [DatabaseIdentifier:11604168] RefSeq:NP_777627.1 [DatabaseIdentifier:11604174] RefSeq:NP_777628.2 [DatabaseIdentifier:11604180] RefSeq:NP_777629.1 [DatabaseIdentifier:11604186] RefSeq:NP_777630.1 [DatabaseIdentifier:11604192] RefSeq:NP_777631.2 [DatabaseIdentifier:11604193] RefSeq:XP_016857602.1 [DatabaseIdentifier:11824311] PRO:Q11203 [DatabaseIdentifier:11846175] GeneCards:Q11203 [DatabaseIdentifier:11883615] Orphanet:20650 [DatabaseIdentifier:11887651] HMDB Protein:HMDBP00207 [DatabaseIdentifier:11899473] HPA:ENSG00000126091-ST3GAL3 [DatabaseIdentifier:12047701] Ensembl:ENSP00000493660 [DatabaseIdentifier:12047702] Ensembl:ENST00000642949 [DatabaseIdentifier:12047703] Ensembl:ENST00000645142 [DatabaseIdentifier:12047704] Ensembl:ENST00000545417 [DatabaseIdentifier:12047705] Ensembl:ENST00000335430 [DatabaseIdentifier:12047706] Ensembl:ENSG00000126091 [DatabaseIdentifier:12047707] Ensembl:ENSP00000317192 [DatabaseIdentifier:12047708] Ensembl:ENSP00000435018 [DatabaseIdentifier:12047709] Ensembl:ENSP00000495887 [DatabaseIdentifier:12047710] Ensembl:ENST00000361400 [DatabaseIdentifier:12047711] Ensembl:ENST00000642504 [DatabaseIdentifier:12047712] Ensembl:ENSP00000494201 [DatabaseIdentifier:12047713] Ensembl:ENST00000262915 [DatabaseIdentifier:12047714] Ensembl:ENST00000351035 [DatabaseIdentifier:12047715] Ensembl:ENST00000530581 [DatabaseIdentifier:12047716] Ensembl:ENST00000531993 [DatabaseIdentifier:12047717] Ensembl:ENSP00000434876 [DatabaseIdentifier:12047718] Ensembl:ENSP00000435603 [DatabaseIdentifier:12047719] Ensembl:ENST00000533212 [DatabaseIdentifier:12047720] Ensembl:ENST00000646971 [DatabaseIdentifier:12047721] Ensembl:ENST00000361392 [DatabaseIdentifier:12047722] Ensembl:ENST00000645640 [DatabaseIdentifier:12047723] Ensembl:ENSP00000355341 [DatabaseIdentifier:12047724] Ensembl:ENST00000642934 [DatabaseIdentifier:12047725] Ensembl:ENST00000490541 [DatabaseIdentifier:12047726] Ensembl:ENSP00000361440 [DatabaseIdentifier:12047727] Ensembl:ENST00000469715 [DatabaseIdentifier:12047728] Ensembl:ENSP00000361441 [DatabaseIdentifier:12047729] Ensembl:ENSP00000361442 [DatabaseIdentifier:12047730] Ensembl:ENSP00000496550 [DatabaseIdentifier:12047731] Ensembl:ENSP00000333494 [DatabaseIdentifier:12047732] Ensembl:ENST00000372362 [DatabaseIdentifier:12047733] Ensembl:ENSP00000335633 [DatabaseIdentifier:12047734] Ensembl:ENST00000645165 [DatabaseIdentifier:12047735] Ensembl:ENST00000372366 [DatabaseIdentifier:12047736] Ensembl:ENSP00000330463 [DatabaseIdentifier:12047737] Ensembl:ENST00000372365 [DatabaseIdentifier:12047738] Ensembl:ENST00000644195 [DatabaseIdentifier:12047739] Ensembl:ENSP00000316999 [DatabaseIdentifier:12047740] Ensembl:ENSP00000354748 [DatabaseIdentifier:12047741] Ensembl:ENST00000372367 [DatabaseIdentifier:12047742] Ensembl:ENST00000372369 [DatabaseIdentifier:12047743] Ensembl:ENST00000353126 [DatabaseIdentifier:12047744] Ensembl:ENSP00000432682 [DatabaseIdentifier:12047745] Ensembl:ENSP00000495709 [DatabaseIdentifier:12047746] Ensembl:ENST00000330208 [DatabaseIdentifier:12047747] Ensembl:ENSP00000361449 [DatabaseIdentifier:12047748] Ensembl:ENSP00000494857 [DatabaseIdentifier:12047749] Ensembl:ENSP00000361444 [DatabaseIdentifier:12047750] Ensembl:ENSP00000494852 [DatabaseIdentifier:12047751] Ensembl:ENST00000347631 [DatabaseIdentifier:12047752] Ensembl:ENSP00000439634 [DatabaseIdentifier:12047753] Ensembl:ENSP00000361447 [DatabaseIdentifier:12047754] Ensembl:ENST00000489897 [DatabaseIdentifier:12047755] Ensembl:ENST00000531816 [DatabaseIdentifier:12047756] Ensembl:ENSP00000494146 [DatabaseIdentifier:12047757] Ensembl:ENST00000361812 [DatabaseIdentifier:12047758] Ensembl:ENSP00000437293 [DatabaseIdentifier:12047759] Ensembl:ENST00000372372 [DatabaseIdentifier:12047760] Ensembl:ENST00000372374 [DatabaseIdentifier:12047761] Ensembl:ENSP00000262915 [DatabaseIdentifier:12047762] Ensembl:ENSP00000434378 [DatabaseIdentifier:12047763] Ensembl:ENSP00000435621 [DatabaseIdentifier:12047764] Ensembl:ENST00000531451 [DatabaseIdentifier:12047765] Ensembl:ENSP00000437206 [DatabaseIdentifier:12047766] Ensembl:ENSP00000355201 [DatabaseIdentifier:12047767] Ensembl:ENSP00000432071 [DatabaseIdentifier:12047768] Ensembl:ENSP00000361437 [DatabaseIdentifier:12047769] Ensembl:ENSP00000431700 [DatabaseIdentifier:12047770] Ensembl:ENST00000533997 [DatabaseIdentifier:12047771] Ensembl:ENST00000528371
databaseName	UniProt
dbId	64474
description	recommendedName: CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase ecNumber evidence="2"2.4.3.6 alternativeName: Beta-galactoside alpha-2,3-sialyltransferase 3 shortName: Alpha 2,3-ST 3 alternativeName: Gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase alternativeName: N-acetyllactosaminide alpha-2,3-sialyltransferase alternativeName: ST3Gal III shortName: ST3GalIII alternativeName: ST3N alternativeName: Sialyltransferase 6
displayName	UniProt:Q11203 ST3GAL3
geneName	ST3GAL3 SIAT6
identifier	Q11203
isSequenceChanged	false
keyword	Alternative splicing Disease variant Disulfide bond Epilepsy Glycoprotein Glycosyltransferase Golgi apparatus Intellectual disability Membrane Reference proteome Secreted Signal-anchor Transferase Transmembrane Transmembrane helix
modified	[InstanceEdit:12187927] Wright, Adam, 2024-03-12
name	ST3GAL3
otherIdentifier	11724137_a_at 11750100_a_at 11753490_a_at 11753789_a_at 11753790_x_at 1555171_PM_at 1555171_at 1555181_PM_a_at 1555181_a_at 1555678_PM_at 1555678_at 1555702_3p_a_at 1555702_PM_a_at 1555702_a_at 1555703_3p_at 1555703_PM_at 1555703_at 16663694 225905_PM_s_at 225905_s_at 2333480 2333482 2333483 2333484 2333488 2333489 2333490 2333507 2333513 2333515 2333516 2333524 2333530 2333531 2333536 2333537 2333539 2333541 2333543 2333544 2333551 2333552 2333553 2333554 2333555 2333556 2333559 2333560 2333561 52958_at 6487 7900857 A_14_P137034 A_23_P200999 A_24_P268123 A_33_P3405966 GE471092 GO:0000139 GO:0003824 GO:0003836 GO:0005515 GO:0005576 GO:0005794 GO:0005975 GO:0006486 GO:0006629 GO:0006790 GO:0008118 GO:0008373 GO:0009312 GO:0010706 GO:0016020 GO:0016266 GO:0016740 GO:0016757 GO:0018146 GO:0019082 GO:0032580 GO:0036211 GO:0043226 GO:1901135 HMNXSV003049671 HMNXSV003053911 Hs.48793.1.S2_3p_at Hs2.48793.3.S1_3p_s_at Hs2.48793.7.S1_3p_s_at Hs2.48793.8.S1_3p_a_at Hs2.48793.9.S1_3p_a_at ILMN_1699472 ILMN_2350315 PH_hs_0003412
physicalEntity	[EntityWithAccessionedSequence:R-HSA-3702102] ST3GAL3 A13D [Golgi membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-3702112] ST3GAL3 D370Y [Golgi membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-3702142] ST3GAL3 A320P [Golgi membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-981488] ST3GAL3 [Golgi membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8997445] ENSEMBL:ENSG00000126091 ST3GAL3 [ReferenceDNASequence:11022943] KEGG Gene (Homo sapiens):6487 ST3GAL3 [ReferenceDNASequence:11231597] NCBI Gene:6487 ST3GAL3 [ReferenceDNASequence:11231598] BioGPS Gene:6487 ST3GAL3 [ReferenceDNASequence:11231599] CTD Gene:6487 ST3GAL3 [ReferenceDNASequence:11231600] dbSNP Gene:6487 ST3GAL3 [ReferenceDNASequence:11231601] Monarch:6487 ST3GAL3 [ReferenceDNASequence:11344446] ENSEMBL_homo_sapiens_GENE:ENSG00000126091.21 ST3GAL3 [ReferenceDNASequence:11513821] UCSC:Q11203 ST3GAL3 [ReferenceDNASequence:11794363] OMIM:606494 ST3GAL3 [ReferenceDNASequence:11873528] HGNC:10866 ST3GAL3 [ReferenceDNASequence:12194092] COSMIC (genes):ST3GAL3 ST3GAL3
referenceTranscript	[ReferenceRNASequence:11466453] RefSeq:NM_001270459.1 ST3GAL3 [ReferenceRNASequence:11466455] RefSeq:NM_001270460.1 ST3GAL3 [ReferenceRNASequence:11466462] RefSeq:NM_001270461.1 ST3GAL3 [ReferenceRNASequence:11466464] RefSeq:NM_001270462.1 ST3GAL3 [ReferenceRNASequence:11466470] RefSeq:NM_001270463.1 ST3GAL3 [ReferenceRNASequence:11466473] RefSeq:NM_001270464.1 ST3GAL3 [ReferenceRNASequence:11466481] RefSeq:NM_001270465.1 ST3GAL3 [ReferenceRNASequence:11466483] RefSeq:NM_001270466.1 ST3GAL3 [ReferenceRNASequence:11466492] RefSeq:NM_006279.3 ST3GAL3 [ReferenceRNASequence:11466494] RefSeq:NM_174963.3 ST3GAL3 [ReferenceRNASequence:11466503] RefSeq:NM_174964.2 ST3GAL3 [ReferenceRNASequence:11466505] RefSeq:NM_174965.2 ST3GAL3 [ReferenceRNASequence:11466514] RefSeq:NM_174966.2 ST3GAL3 [ReferenceRNASequence:11466516] RefSeq:NM_174967.2 ST3GAL3 [ReferenceRNASequence:11466524] RefSeq:NM_174968.3 ST3GAL3 [ReferenceRNASequence:11466526] RefSeq:NM_174969.2 ST3GAL3 [ReferenceRNASequence:11466534] RefSeq:NM_174970.2 ST3GAL3 [ReferenceRNASequence:11466536] RefSeq:NM_174971.3 ST3GAL3 [ReferenceRNASequence:11466543] RefSeq:XM_017002113.1 ST3GAL3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	SIAT6_HUMAN A9Z1W2 D3DPX8 Q5T4W9 Q5T4X0 Q5T4X7 Q5T4X8 Q5T4X9 Q5T4Y0 Q5T4Y2 Q5T4Y3 Q5T4Y4 Q86UR6 Q86UR7 Q86UR8 Q86UR9 Q86US0 Q86US1 Q86US2 Q8IX41 Q8IX42 Q8IX43 Q8IX44 Q8IX45 Q8IX46 Q8IX47 Q8IX48 Q8IX49 Q8IX50 Q8IX51 Q8IX52 Q8IX53 Q8IX54 Q8IX55 Q8IX56 Q8IX57 Q8IX58
sequenceLength	375
species	[Species:48887] Homo sapiens
url	https://purl.uniprot.org/uniprot/Q11203

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-3702102] ST3GAL3 A13D [Golgi membrane] [EntityWithAccessionedSequence:R-HSA-3702112] ST3GAL3 D370Y [Golgi membrane] [EntityWithAccessionedSequence:R-HSA-3702142] ST3GAL3 A320P [Golgi membrane] [EntityWithAccessionedSequence:R-HSA-981488] ST3GAL3 [Golgi membrane]
(referenceSequence)	[ReplacedResidue:3702105] L-alanine 13 replaced with L-aspartic acid [ReplacedResidue:3702104] L-aspartic acid 370 replaced with L-tyrosine [ReplacedResidue:3702141] L-alanine 320 replaced with L-proline
(interactor)	[UndirectedInteraction:12230395] UniProt:Q11203 <-> UniProt:Q8N7X4 (IntAct) [UndirectedInteraction:12230391] UniProt:Q11203 <-> UniProt:Q86TI2-2 (IntAct)

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