UniProt:Q15465 SHH

chain
  • signal peptide:1-23
  • chain:24-462
  • chain:24-197
checksum DD687AFA582A4749
comment
  • SUBUNIT Interacts with HHATL/GUP1 which negatively regulates HHAT-mediated palmitoylation of the SHH N-terminus (By similarity). ShhNp is active as a multimer (PubMed:24522195). Interacts with BOC and CDON (By similarity). Interacts with HHIP (PubMed:19561609). Interacts with DISP1 via its cholesterol anchor (PubMed:22902404, PubMed:22677548). Interacts with SCUBE2 (PubMed:24522195, PubMed:22677548). Interacts with glypican GPC3 (By similarity).SIMILARITY Belongs to the hedgehog family.CAUTION The several steps and mechanisms that permit controlled Shh dispersion and gradient formation remain controversial. The ShhNC C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity resulting in the cleavage and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (ShhN). The protein is further modified by covalent addition of palmitate at the N-terminal of ShhN, resulting to the dual-lipidated Shh (ShhNp). ShhNp is firmly tethered to the cell membrane where it forms multimers. Further solubilization and release from the cell surface seem to be achieved through different mechanisms, including the interaction with DISP1 and SCUBE2, movement by lipoprotein particles, transport by cellular extensions called cytonemes or by proteolytic removal of both terminal lipidated peptides (PubMed:26875496). Once released, the fully processed Shh can signal within embryonic tissues both at short and long-range.
crossReference
databaseName UniProt
dbId 64432
description
  • recommendedName: Sonic hedgehog protein shortName:SHH alternativeName: HHG-1 alternativeName: fullName evidence="34"Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains shortName evidence="34"ShhNC component recommendedName: Sonic hedgehog protein N-product shortName:ShhN alternativeName: fullName evidence="34"Shh N-terminal processed signaling domains shortName evidence="34"ShhNp /component
displayName UniProt:Q15465 SHH
geneName
  • SHH
identifier Q15465
isSequenceChanged false
keyword
  • 3D-structure
  • Autocatalytic cleavage
  • Calcium
  • Cell membrane
  • Developmental protein
  • Direct protein sequencing
  • Disease variant
  • Glycoprotein
  • Holoprosencephaly
  • Hydrolase
  • Lipoprotein
  • Membrane
  • Metal-binding
  • Microphthalmia
  • Palmitate
  • Protease
  • Reference proteome
  • Signal
  • Zinc
modified [InstanceEdit:11703684] Shorser, Solomon, 2021-05-28
name
  • SHH
otherIdentifier
  • 0002970504
  • 11738265_at
  • 17064810
  • 207586_at
  • 236263_at
  • 3081218
  • 3081219
  • 3081220
  • 3081221
  • 3081222
  • 3081223
  • 3081224
  • 3081225
  • 3081226
  • 3081227
  • 3081229
  • 3081230
  • 3081231
  • 31724_at
  • 59360_at
  • 6469
  • 70121_at
  • 8144078
  • A_23_P111657
  • GE619667
  • GO:0000003
  • GO:0000122
  • GO:0000902
  • GO:0001525
  • GO:0001569
  • GO:0001570
  • GO:0001656
  • GO:0001658
  • GO:0001708
  • GO:0001755
  • GO:0001822
  • GO:0001942
  • GO:0001944
  • GO:0001947
  • GO:0002052
  • GO:0002053
  • GO:0002076
  • GO:0002320
  • GO:0002376
  • GO:0003140
  • GO:0003674
  • GO:0005113
  • GO:0005509
  • GO:0005515
  • GO:0005539
  • GO:0005575
  • GO:0005576
  • GO:0005615
  • GO:0005622
  • GO:0005737
  • GO:0005783
  • GO:0005788
  • GO:0005829
  • GO:0005886
  • GO:0006355
  • GO:0006508
  • GO:0006629
  • GO:0006810
  • GO:0006897
  • GO:0006913
  • GO:0006950
  • GO:0007010
  • GO:0007155
  • GO:0007165
  • GO:0007224
  • GO:0007228
  • GO:0007267
  • GO:0007275
  • GO:0007368
  • GO:0007389
  • GO:0007398
  • GO:0007405
  • GO:0007411
  • GO:0007417
  • GO:0007418
  • GO:0007442
  • GO:0007507
  • GO:0007596
  • GO:0008150
  • GO:0008209
  • GO:0008219
  • GO:0008233
  • GO:0008270
  • GO:0008283
  • GO:0008284
  • GO:0009056
  • GO:0009058
  • GO:0009790
  • GO:0009880
  • GO:0009949
  • GO:0009952
  • GO:0009953
  • GO:0009986
  • GO:0010463
  • GO:0010468
  • GO:0010628
  • GO:0010629
  • GO:0014003
  • GO:0014706
  • GO:0014858
  • GO:0014902
  • GO:0015031
  • GO:0016015
  • GO:0016020
  • GO:0016192
  • GO:0016539
  • GO:0016540
  • GO:0016787
  • GO:0021513
  • GO:0021522
  • GO:0021794
  • GO:0021871
  • GO:0021904
  • GO:0021924
  • GO:0021930
  • GO:0021938
  • GO:0021940
  • GO:0021978
  • GO:0030010
  • GO:0030154
  • GO:0030162
  • GO:0030177
  • GO:0030178
  • GO:0030323
  • GO:0030324
  • GO:0030326
  • GO:0030336
  • GO:0030539
  • GO:0030850
  • GO:0030878
  • GO:0030900
  • GO:0030901
  • GO:0030902
  • GO:0031012
  • GO:0031016
  • GO:0031069
  • GO:0032435
  • GO:0033077
  • GO:0033089
  • GO:0033092
  • GO:0034244
  • GO:0034504
  • GO:0034641
  • GO:0035115
  • GO:0035116
  • GO:0040007
  • GO:0040011
  • GO:0042127
  • GO:0042130
  • GO:0042177
  • GO:0042307
  • GO:0042475
  • GO:0042476
  • GO:0042481
  • GO:0042733
  • GO:0043010
  • GO:0043066
  • GO:0043167
  • GO:0043226
  • GO:0043237
  • GO:0043369
  • GO:0043588
  • GO:0045059
  • GO:0045060
  • GO:0045109
  • GO:0045121
  • GO:0045165
  • GO:0045445
  • GO:0045596
  • GO:0045597
  • GO:0045880
  • GO:0045893
  • GO:0045944
  • GO:0046638
  • GO:0046639
  • GO:0046872
  • GO:0048468
  • GO:0048538
  • GO:0048546
  • GO:0048557
  • GO:0048568
  • GO:0048589
  • GO:0048598
  • GO:0048617
  • GO:0048643
  • GO:0048645
  • GO:0048646
  • GO:0048663
  • GO:0048706
  • GO:0048709
  • GO:0048714
  • GO:0048745
  • GO:0048754
  • GO:0048839
  • GO:0048856
  • GO:0048859
  • GO:0048864
  • GO:0048870
  • GO:0051146
  • GO:0051155
  • GO:0051301
  • GO:0051604
  • GO:0051781
  • GO:0060020
  • GO:0060021
  • GO:0060070
  • GO:0060173
  • GO:0060174
  • GO:0060425
  • GO:0060428
  • GO:0060438
  • GO:0060439
  • GO:0060441
  • GO:0060442
  • GO:0060445
  • GO:0060447
  • GO:0060458
  • GO:0060459
  • GO:0060463
  • GO:0060484
  • GO:0060516
  • GO:0060523
  • GO:0060662
  • GO:0060664
  • GO:0060684
  • GO:0060685
  • GO:0060738
  • GO:0060768
  • GO:0060769
  • GO:0060782
  • GO:0060783
  • GO:0060840
  • GO:0060916
  • GO:0061053
  • GO:0061189
  • GO:0062023
  • GO:0071285
  • GO:0071542
  • GO:0072136
  • GO:0072205
  • GO:0090090
  • GO:0090370
  • GO:0097190
  • GO:1900175
  • GO:1900180
  • GO:1904339
  • GO:1905327
  • GO:2000062
  • GO:2000063
  • GO:2000357
  • GO:2000358
  • GO:2000729
  • GO:2001054
  • HMNXSV003038694
  • Hs.164537.0.A1_3p_at
  • ILMN_1652693
  • PH_hs_0006769
  • PH_hs_0009949
  • TC07002064.hg
  • g4506938_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • SHH_HUMAN
  • A4D247
  • Q75MC9
sequenceLength 462
species [Species:48887] Homo sapiens
url http://purl.uniprot.org/uniprot/Q15465

Referrals

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