UniProt:Q92781 RDH5

chain
  • chain:1-318
checksum 2CE24343F2EEA4B7
comment
  • FUNCTION Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:11675386, PubMed:10588954, PubMed:9931293, PubMed:9115228). Has no activity towards all-trans retinal (By similarity). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates (PubMed:9931293, PubMed:29541409).ACTIVITY REGULATION Inhibited by 9-cis-, 13-cis- and all-trans-retinoic acids, with the most potent inhibitor being 13-cis-retinoic acid. Weakly inhibited by oleic acid.PATHWAY Cofactor metabolism; retinol metabolism.SUBUNIT Homodimer.TISSUE SPECIFICITY Widely expressed. In the eye, abundant in the retinal pigment epithelium.DOMAIN The last 8 amino acids of the C-terminal tail are important for a proper localization as well as for the in vivo enzymatic activity.SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family.
crossReference
databaseName UniProt
dbId 62906
description
  • recommendedName: Retinol dehydrogenase 5 ecNumber evidence="19 21"1.1.1.209/ecNumber ecNumber evidence="6 12 21"1.1.1.315/ecNumber ecNumber evidence="21"1.1.1.53/ecNumber alternativeName: fullName evidence="23"11-cis retinol dehydrogenase shortName:11-cis RDH shortName:11-cis RoDH alternativeName: 9-cis retinol dehydrogenase shortName:9cRDH alternativeName: fullName evidence="22"Short chain dehydrogenase/reductase family 9C member 5
displayName UniProt:Q92781 RDH5
geneName
  • RDH5
  • HSD17B9
  • RDH1
  • SDR9C5
identifier Q92781
isSequenceChanged false
keyword
  • Disease variant
  • Endoplasmic reticulum
  • Glycoprotein
  • Lipid metabolism
  • Membrane
  • NAD
  • Oxidoreductase
  • Reference proteome
  • Sensory transduction
  • Steroid metabolism
  • Transmembrane
  • Transmembrane helix
  • Vision
modified [InstanceEdit:11703684] Shorser, Solomon, 2021-05-28
name
  • RDH5
otherIdentifier
  • 0002850541
  • 11724965_at
  • 11724966_s_at
  • 210106_at
  • 32727_at
  • 3416922
  • 3416924
  • 3416925
  • 3416926
  • 3416927
  • 3416930
  • 3416932
  • 3416934
  • 3416935
  • 3416936
  • 5959
  • 7956018
  • GE54293
  • GO:0001523
  • GO:0003674
  • GO:0004745
  • GO:0005575
  • GO:0005622
  • GO:0005737
  • GO:0005783
  • GO:0005788
  • GO:0005789
  • GO:0006629
  • GO:0007601
  • GO:0008150
  • GO:0008202
  • GO:0016020
  • GO:0016021
  • GO:0016491
  • GO:0042572
  • GO:0042803
  • GO:0043226
  • GO:0044281
  • GO:0047023
  • GO:0047044
  • GO:0050877
  • GO:0050896
  • GO:0055114
  • HMNXSV003023337
  • ILMN_1773395
  • TC12003300.hg
  • U89717_at
  • g1616653_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RDH5_HUMAN
  • O00179
  • Q8TAI2
sequenceLength 318
species [Species:48887] Homo sapiens
url http://purl.uniprot.org/uniprot/Q92781
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