UniProt:P57735 RAB25

chain
  • chain:1-210
  • propeptide:211-213
checksum 119523C3036C370E
comment
  • FUNCTION Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity).SUBUNIT Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Interacts (via the hypervariable C-terminal region) with ITGB1 (via the cytoplasmic region); the interaction is GTP-dependent. Interacts with ITGAV. Associates with the integrin alpha-V/beta-1 heterodimer. Interacts with VPS33B (PubMed:28017832).INTERACTION Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips.TISSUE SPECIFICITY Expressed in ovarian epithelium (NOE) and breast tissue. Expressed in ovarian cancer; expression is increased relative to NOE cells. Expression in ovarian cancer is stage dependent, with stage III and stage IV showing higher levels than early stage cancers. Expressed in breast cancer; expression is increased relative to normal breast tissue.SIMILARITY Belongs to the small GTPase superfamily. Rab family.SEQUENCE CAUTION Extended N-terminus.
crossReference
databaseName UniProt
dbId 62760
description
  • recommendedName: Ras-related protein Rab-25 alternativeName: CATX-8
displayName UniProt:P57735 RAB25
geneName
  • RAB25
  • CATX8
identifier P57735
isSequenceChanged false
keyword
  • 3D-structure
  • Cell membrane
  • Cell projection
  • Cytoplasmic vesicle
  • GTP-binding
  • Lipoprotein
  • Membrane
  • Methylation
  • Nucleotide-binding
  • Prenylation
  • Protein transport
  • Reference proteome
  • Transport
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • RAB25
otherIdentifier
  • 11729639_at
  • 16671901
  • 218186_PM_at
  • 218186_at
  • 2361258
  • 2361259
  • 2361262
  • 2361266
  • 2361267
  • 2361269
  • 2361270
  • 48963_at
  • 57111
  • 7906079
  • A_23_P115091
  • GE82535
  • GE88647
  • GO:0000166
  • GO:0003382
  • GO:0003824
  • GO:0003924
  • GO:0005515
  • GO:0005525
  • GO:0005576
  • GO:0005615
  • GO:0005768
  • GO:0005794
  • GO:0005886
  • GO:0006887
  • GO:0008092
  • GO:0008284
  • GO:0010634
  • GO:0015031
  • GO:0016020
  • GO:0016192
  • GO:0016787
  • GO:0030154
  • GO:0031143
  • GO:0031260
  • GO:0031268
  • GO:0031410
  • GO:0031489
  • GO:0042995
  • GO:0043226
  • GO:0048856
  • GO:0048870
  • GO:0055037
  • GO:0060627
  • GO:0070062
  • ILMN_1791826
  • PH_hs_0009084
  • TC01001311.hg
  • g9966860_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RAB25_HUMAN
  • Q5VYA2
  • Q8NG24
  • Q96GB1
  • Q9BT12
sequenceLength 213
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/P57735
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