UniProt:P01116 KRAS

chain
  • initiator methionine:1
  • chain:1-186
  • chain:2-186
  • propeptide:187-189
checksum 973547B2E11C2C81
comment
  • FUNCTION Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621). Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306).ACTIVITY REGULATION Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Interaction with SOS1 promotes exchange of bound GDP by GTP.SUBUNIT Interacts with PHLPP. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts (when farnesylated) with PDE6D; this promotes dissociation from the cell membrane (PubMed:23698361). Interacts with SOS1 (PubMed:22431598). Interacts (when farnesylated) with GPR31 (PubMed:28619714).PTM Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).PTM Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.PTM (Microbial infection) Glucosylated at Thr-35 by P.sordellii toxin TcsL.DISEASE Defects in KRAS are a cause of pylocytic astrocytoma (PA). Pylocytic astrocytomas are neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors.DISEASE KRAS mutations are involved in cancer development.SIMILARITY Belongs to the small GTPase superfamily. Ras family.
crossReference
databaseName UniProt
dbId 62720
description
  • recommendedName: GTPase KRas ecNumber evidence="17"3.6.5.2/ecNumber alternativeName: K-Ras 2 alternativeName: Ki-Ras alternativeName: c-K-ras alternativeName: c-Ki-ras component recommendedName: GTPase KRas, N-terminally processed /component
displayName UniProt:P01116 KRAS
geneName
  • KRAS
  • KRAS2
  • RASK2
identifier P01116
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Cardiomyopathy
  • Cell membrane
  • Cytoplasm
  • Deafness
  • Direct protein sequencing
  • Disease variant
  • Ectodermal dysplasia
  • Glycoprotein
  • GTP-binding
  • Hydrolase
  • Isopeptide bond
  • Lipoprotein
  • Membrane
  • Mental retardation
  • Methylation
  • Nucleotide-binding
  • Palmitate
  • Prenylation
  • Proto-oncogene
  • Reference proteome
  • Ubl conjugation
modified [InstanceEdit:11703684] Shorser, Solomon, 2021-05-28
name
  • KRAS
otherIdentifier
  • 0006110070
  • 0007040129
  • 11717962_x_at
  • 11717963_a_at
  • 11717964_a_at
  • 11717965_s_at
  • 16762399
  • 1940_at
  • 204009_s_at
  • 204010_s_at
  • 214352_s_at
  • 231640_at
  • 32159_at
  • 3447860
  • 3447862
  • 3447864
  • 3447865
  • 3447866
  • 3447867
  • 3447868
  • 3447869
  • 3447870
  • 3447871
  • 3447872
  • 3447873
  • 3447874
  • 3447879
  • 3447880
  • 3447884
  • 3447886
  • 3845
  • 3958621
  • 7961865
  • A_23_P306500
  • A_23_P306507
  • A_23_P45140
  • A_33_P3317815
  • GE61031
  • GO:0000003
  • GO:0000139
  • GO:0000165
  • GO:0000166
  • GO:0001889
  • GO:0001934
  • GO:0002223
  • GO:0002376
  • GO:0003674
  • GO:0003924
  • GO:0003925
  • GO:0005515
  • GO:0005525
  • GO:0005575
  • GO:0005622
  • GO:0005737
  • GO:0005739
  • GO:0005741
  • GO:0005783
  • GO:0005789
  • GO:0005794
  • GO:0005829
  • GO:0005886
  • GO:0005925
  • GO:0006464
  • GO:0006950
  • GO:0007010
  • GO:0007165
  • GO:0007265
  • GO:0007267
  • GO:0007565
  • GO:0007568
  • GO:0008150
  • GO:0008219
  • GO:0008283
  • GO:0008284
  • GO:0008542
  • GO:0009058
  • GO:0010628
  • GO:0016020
  • GO:0016787
  • GO:0019002
  • GO:0019003
  • GO:0019221
  • GO:0021897
  • GO:0030036
  • GO:0030154
  • GO:0030275
  • GO:0031234
  • GO:0031647
  • GO:0032228
  • GO:0034641
  • GO:0035022
  • GO:0035900
  • GO:0038002
  • GO:0042592
  • GO:0042802
  • GO:0043167
  • GO:0043226
  • GO:0043406
  • GO:0043524
  • GO:0044877
  • GO:0045121
  • GO:0045596
  • GO:0048169
  • GO:0048856
  • GO:0048873
  • GO:0050877
  • GO:0051000
  • GO:0051092
  • GO:0051146
  • GO:0051384
  • GO:0051385
  • GO:0060441
  • GO:2000774
  • HMNXSV003005517
  • HMNXSV003016084
  • Hs.184050.0.S1_3p_a_at
  • Hs.184050.1.A1_3p_a_at
  • Hs.184050.4.A1_3p_at
  • ILMN_1652104
  • ILMN_1728071
  • M54968_at
  • PH_hs_0028364
  • PH_hs_0030345
  • TC12001314.hg
  • g4826811_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RASK_HUMAN
  • A8K8Z5
  • B0LPF9
  • P01118
  • Q96D10
sequenceLength 189
species [Species:48887] Homo sapiens
url http://purl.uniprot.org/uniprot/P01116

Referrals

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(isoformParent)
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