Reactome | UniProt:Q06141 REG3A

Schema > ReferenceGeneProduct > Entries

UniProt:Q06141 REG3A Show undefined attributes

chain	signal peptide:1-26 chain:27-175 propeptide:27-37 chain:38-175
checksum	C51149FAC22EB68C
comment	FUNCTION Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan (PubMed:16931762). Binds membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing oligomeric pore (PubMed:24256734).FUNCTION Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways (PubMed:22727489, PubMed:19158046, PubMed:34099862, PubMed:27830702). Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway (PubMed:22727489). In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF (PubMed:27830702). In pancreas, is able to permealize beta-cells membrane and stimulate their proliferation (PubMed:19158046).FUNCTION Has bacteriostatic activity.ACTIVITY REGULATION Lipopolysaccharide inhibits pore-forming activity, explaining why is bactericidal for Gram-positive but not Gram-negative bacteria.SUBUNIT Forms a hexameric membrane-permeabilizing oligomeric pore on membrane phospholipids. The hexamer is formed by three dimers related by helical symmetry (PubMed:24256734). Forms filaments, filamentation traps pore complexes and limits damage to host cells (PubMed:24256734). Interacts with EXTL3.INTERACTION Found in the apical region of pancreatic acinar cells.TISSUE SPECIFICITY Expressed by keratinocytes (PubMed:27830702). Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level) (PubMed:22727489). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis (PubMed:1469087).INDUCTION Appears in pancreatic juice after induction of pancreatic inflammation (PubMed:19254208). Induced by IL17A and IL33 during skin inflammation (PubMed:27830702).DOMAIN The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.PTM Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.ONLINE INFORMATION Pancreatitis-associated protein 1
crossReference	[DatabaseIdentifier:10977498] Pharos - Targets:Q06141 [DatabaseIdentifier:11079943] OpenTargets:ENSG00000172016 [DatabaseIdentifier:11621718] RefSeq:NP_002571.1 [DatabaseIdentifier:11621720] RefSeq:NP_620354.1 [DatabaseIdentifier:11621728] RefSeq:NP_620355.1 [DatabaseIdentifier:11776515] PDB:1UV0 [DatabaseIdentifier:11776519] PDB:2GO0 [DatabaseIdentifier:11776527] PDB:4MTH [DatabaseIdentifier:11835309] PRO:Q06141 [DatabaseIdentifier:11852226] GeneCards:Q06141 [DatabaseIdentifier:11902860] HPA:ENSG00000172016-REG3A [DatabaseIdentifier:12179001] Ensembl:ENSP00000377456 [DatabaseIdentifier:12179002] Ensembl:ENST00000305165 [DatabaseIdentifier:12179003] Ensembl:ENST00000409839 [DatabaseIdentifier:12179004] Ensembl:ENSP00000386630 [DatabaseIdentifier:12179005] Ensembl:ENSP00000304311 [DatabaseIdentifier:12179006] Ensembl:ENSG00000172016 [DatabaseIdentifier:12179007] Ensembl:ENST00000393878
databaseName	UniProt
dbId	61300
description	recommendedName: Regenerating islet-derived protein 3-alpha shortName: REG-3-alpha alternativeName: Hepatointestinal pancreatic protein shortName: HIP/PAP alternativeName: fullName evidence="12"Human proislet peptide shortName evidence="12"HIP alternativeName: Pancreatitis-associated protein 1 alternativeName: Regenerating islet-derived protein III-alpha shortName: Reg III-alpha component recommendedName: Regenerating islet-derived protein 3-alpha 16.5 kDa form /component component recommendedName: Regenerating islet-derived protein 3-alpha 15 kDa form /component
displayName	UniProt:Q06141 REG3A
geneName	REG3A HIP PAP PAP1
identifier	Q06141
isSequenceChanged	false
keyword	3D-structure Acute phase Antimicrobial Direct protein sequencing Disulfide bond Inflammatory response Lectin Reference proteome Secreted Signal
modified	[InstanceEdit:12187927] Wright, Adam, 2024-03-12
name	REG3A
otherIdentifier	11719674_at 16899509 205815_PM_at 205815_at 234280_PM_at 234280_at 2490308 2490311 2490314 2561217 2561218 2561219 2561220 2561223 2561226 2561228 2561230 2561231 2561232 2561233 39946_at 5068 8053341 A_23_P119936 D30715_xpt5_s_at GE79638 GO:0002376 GO:0005179 GO:0005515 GO:0005576 GO:0005615 GO:0005737 GO:0006953 GO:0006954 GO:0007155 GO:0007157 GO:0007165 GO:0008284 GO:0009609 GO:0009611 GO:0010838 GO:0023052 GO:0030154 GO:0030246 GO:0038023 GO:0042060 GO:0042802 GO:0042834 GO:0043434 GO:0045617 GO:0048018 GO:0048856 GO:0050728 GO:0060089 GO:0061844 GO:0070492 GO:0090303 GO:0098542 GO:0098772 GO:0106015 GO:2000972 HMNXSV003051278 Hs.306333.0.S1_3p_at ILMN_1757504 ILMN_2382679 L15533_rna1_at PH_hs_0000050 TC02002019.hg g4505604_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6801352] REG3A(38-175) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6801783] REG3A(27-37) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6801803] REG3A(27-175) [extracellular region] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8996212] ENSEMBL:ENSG00000172016 REG3A [ReferenceDNASequence:11030318] KEGG Gene (Homo sapiens):5068 REG3A [ReferenceDNASequence:11277910] NCBI Gene:5068 REG3A [ReferenceDNASequence:11277911] BioGPS Gene:5068 REG3A [ReferenceDNASequence:11277912] CTD Gene:5068 REG3A [ReferenceDNASequence:11277913] dbSNP Gene:5068 REG3A [ReferenceDNASequence:11277914] Monarch:5068 REG3A [ReferenceDNASequence:11351623] ENSEMBL_homo_sapiens_GENE:ENSG00000172016.16 REG3A [ReferenceDNASequence:11801920] OMIM:167805 REG3A [ReferenceDNASequence:11879572] HGNC:8601 REG3A [ReferenceDNASequence:12192252] COSMIC (genes):REG3A REG3A
referenceTranscript	[ReferenceRNASequence:11453195] RefSeq:NM_002580.2 REG3A [ReferenceRNASequence:11453196] RefSeq:NM_138937.2 REG3A [ReferenceRNASequence:11453210] RefSeq:NM_138938.2 REG3A
schemaClass	ReferenceGeneProduct
secondaryIdentifier	REG3A_HUMAN
sequenceLength	175
species	[Species:48887] Homo sapiens
url	https://purl.uniprot.org/uniprot/Q06141

Referrals

(interactor)	[UndirectedInteraction:12209919] UniProt:Q06141 <-> UniProt:Q06141 (IntAct) [UndirectedInteraction:12209919] UniProt:Q06141 <-> UniProt:Q06141 (IntAct) [UndirectedInteraction:12209917] UniProt:Q06141 <-> UniProt:Q99750 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-6801352] REG3A(38-175) [extracellular region] [EntityWithAccessionedSequence:R-HSA-6801783] REG3A(27-37) [extracellular region] [EntityWithAccessionedSequence:R-HSA-6801803] REG3A(27-175) [extracellular region]