UniProt:Q06495 SLC34A1

chain
  • chain:1-639
checksum 65D21D968C35D61B
comment
  • FUNCTION Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:26047794, PubMed:8327470, PubMed:12324554, PubMed:20335586). The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic (By similarity).CATALYTIC ACTIVITY 3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in)BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 8.0.SUBUNIT Interacts via its C-terminal region with NHERF4 (By similarity). Interacts with NHERF1 (PubMed:22506049). Interacts with TMEM174; regulates SLC34A1 internalization by PTH and FGF23 (By similarity).SUBCELLULAR LOCATION Localized at the brush border membranes of the proximal tubules. Internalized from the cell surface upon PTH stimulation.ALTERNATIVE PRODUCTS Kidney and lung.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the SLC34A transporter family.
crossReference
databaseName UniProt
dbId 60414
description
  • recommendedName: Sodium-dependent phosphate transport protein 2A shortName: Sodium-phosphate transport protein 2A alternativeName: Na(+)-dependent phosphate cotransporter 2A alternativeName: fullName evidence="10"NaPi-3 alternativeName: Sodium/phosphate cotransporter 2A shortName: Na(+)/Pi cotransporter 2A shortName: NaPi-2a alternativeName: fullName evidence="13"Solute carrier family 34 member 1
displayName UniProt:Q06495 SLC34A1
geneName
  • SLC34A1
  • NPT2
  • SLC17A2
identifier Q06495
isSequenceChanged false
keyword
  • Alternative splicing
  • Cell membrane
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Ion transport
  • Membrane
  • Phosphoprotein
  • Reference proteome
  • Sodium
  • Sodium transport
  • Symport
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • SLC34A1
otherIdentifier
  • 11733578_a_at
  • 11747701_a_at
  • 11760532_a_at
  • 16993065
  • 208177_PM_at
  • 208177_at
  • 2843133
  • 2843134
  • 2843135
  • 2843136
  • 2843137
  • 2843139
  • 2843140
  • 2843142
  • 2843144
  • 2843146
  • 2843149
  • 2843150
  • 2843152
  • 2843153
  • 2843154
  • 2843155
  • 2843158
  • 2843159
  • 31328_at
  • 6569
  • 69446_at
  • 8110347
  • A_21_P0000067
  • A_23_P58729
  • GE57623
  • GO:0001503
  • GO:0001822
  • GO:0005215
  • GO:0005436
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005768
  • GO:0005829
  • GO:0005856
  • GO:0005886
  • GO:0005903
  • GO:0006811
  • GO:0006814
  • GO:0006817
  • GO:0007584
  • GO:0009100
  • GO:0009410
  • GO:0009986
  • GO:0010288
  • GO:0015293
  • GO:0016020
  • GO:0016036
  • GO:0016324
  • GO:0016607
  • GO:0019538
  • GO:0030165
  • GO:0030643
  • GO:0031410
  • GO:0031526
  • GO:0031982
  • GO:0032026
  • GO:0032355
  • GO:0033189
  • GO:0035435
  • GO:0035864
  • GO:0042431
  • GO:0042802
  • GO:0043226
  • GO:0043434
  • GO:0044341
  • GO:0044877
  • GO:0045838
  • GO:0046686
  • GO:0046689
  • GO:0048471
  • GO:0048856
  • GO:0055062
  • GO:0055085
  • GO:0060416
  • GO:0071107
  • GO:0071248
  • GO:0071374
  • GO:0072350
  • GO:0072686
  • GO:0072734
  • GO:0097066
  • GO:0097187
  • GO:0098719
  • GO:1901128
  • GO:1901135
  • GO:1901652
  • GO:1901684
  • GO:2000120
  • GO:2000187
  • HMNXSV003000981
  • HMNXSV003055901
  • ILMN_1659991
  • L13258_at
  • PH_hs_0000120
  • TC05001014.hg
  • g4506984_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • NPT2A_HUMAN
  • B4DPE3
sequenceLength 639
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/Q06495
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