Reactome | UniProt:P30419 NMT1

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UniProt:P30419 NMT1 Show undefined attributes

chain	chain:1-496
checksum	7661140D3837BE7A
comment	FUNCTION Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:22865860, PubMed:32686708, PubMed:34999170, PubMed:25255805, PubMed:9353336, PubMed:9506952). Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3' (PubMed:32103017, PubMed:32111831). Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle (PubMed:32103017).CATALYTIC ACTIVITY N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]CATALYTIC ACTIVITY N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein]BIOPHYSICOCHEMICAL PROPERTIES kcat is 0.41 sec(-1) with tetradecanoyl-CoA as substrate.INTERACTION Copurifies with ribosomes.ALTERNATIVE PRODUCTS Heart, gut, kidney, liver and placenta.SIMILARITY Belongs to the NMT family.
crossReference	[DatabaseIdentifier:10971710] Pharos - Targets:P30419 [DatabaseIdentifier:11055819] OpenTargets:ENSG00000136448 [DatabaseIdentifier:11625665] RefSeq:NP_066565.1 [DatabaseIdentifier:11787760] PDB:1RXT [DatabaseIdentifier:11787762] PDB:3IU1 [DatabaseIdentifier:11787764] PDB:3IU2 [DatabaseIdentifier:11787766] PDB:3IWE [DatabaseIdentifier:11787768] PDB:3JTK [DatabaseIdentifier:11787770] PDB:4C2Y [DatabaseIdentifier:11787772] PDB:4C2Z [DatabaseIdentifier:11787774] PDB:5MU6 [DatabaseIdentifier:11787776] PDB:5NPQ [DatabaseIdentifier:11787778] PDB:5O6H [DatabaseIdentifier:11787780] PDB:5O6J [DatabaseIdentifier:11787782] PDB:5O9S [DatabaseIdentifier:11787784] PDB:5O9T [DatabaseIdentifier:11787786] PDB:5O9U [DatabaseIdentifier:11787787] PDB:5O9V [DatabaseIdentifier:11787789] PDB:5UUT [DatabaseIdentifier:11787791] PDB:6EHJ [DatabaseIdentifier:11787793] PDB:6F56 [DatabaseIdentifier:11787795] PDB:6FZ2 [DatabaseIdentifier:11787797] PDB:6FZ3 [DatabaseIdentifier:11787799] PDB:6FZ5 [DatabaseIdentifier:11787801] PDB:6PAV [DatabaseIdentifier:11787803] PDB:6QRM [DatabaseIdentifier:11787805] PDB:6SJZ [DatabaseIdentifier:11787807] PDB:6SK2 [DatabaseIdentifier:11787809] PDB:6SK3 [DatabaseIdentifier:11787811] PDB:6SK8 [DatabaseIdentifier:11787813] PDB:6SKJ [DatabaseIdentifier:11787815] PDB:7OWM [DatabaseIdentifier:11787817] PDB:7OWN [DatabaseIdentifier:11787819] PDB:7OWO [DatabaseIdentifier:11787821] PDB:7OWP [DatabaseIdentifier:11787823] PDB:7OWQ [DatabaseIdentifier:11787829] PDB:7OWR [DatabaseIdentifier:11787830] PDB:7OWU [DatabaseIdentifier:11787831] PDB:7RK3 [DatabaseIdentifier:11805426] PRO:P30419 [DatabaseIdentifier:11842324] GeneCards:P30419 [DatabaseIdentifier:11852575] ZINC - Substances:NMT1_HUMAN [DatabaseIdentifier:11861171] ZINC - Predictions - Purchasable:NMT1_HUMAN [DatabaseIdentifier:11863462] ZINC target:P30419 [DatabaseIdentifier:11889235] HMDB Protein:HMDBP01578 [DatabaseIdentifier:11892504] HPA:ENSG00000136448-NMT1 [DatabaseIdentifier:11965181] Ensembl:ENSP00000466827 [DatabaseIdentifier:11965182] Ensembl:ENSP00000258960 [DatabaseIdentifier:11965183] Ensembl:ENSP00000503621 [DatabaseIdentifier:11965184] Ensembl:ENST00000258960 [DatabaseIdentifier:11965185] Ensembl:ENSP00000504192 [DatabaseIdentifier:11965186] Ensembl:ENST00000592654 [DatabaseIdentifier:11965187] Ensembl:ENSG00000136448 [DatabaseIdentifier:11965188] Ensembl:ENSP00000468424 [DatabaseIdentifier:11965189] Ensembl:ENST00000592782 [DatabaseIdentifier:11965190] Ensembl:ENST00000676828 [DatabaseIdentifier:11965191] Ensembl:ENST00000678938
databaseName	UniProt
dbId	60307
description	recommendedName: fullName evidence="17"Glycylpeptide N-tetradecanoyltransferase 1 ecNumber evidence="4 5 10 11"2.3.1.97 alternativeName: Myristoyl-CoA:protein N-myristoyltransferase 1 shortName evidence="14"HsNMT1 shortName: NMT 1 shortName: Type I N-myristoyltransferase alternativeName: Peptide N-myristoyltransferase 1 alternativeName: fullName evidence="17"Protein-lysine myristoyltransferase NMT1 ecNumber evidence="6 7"2.3.1.-
displayName	UniProt:P30419 NMT1
geneName	NMT1 NMT
identifier	P30419
isSequenceChanged	false
keyword	3D-structure Acyltransferase Alternative splicing Cytoplasm Membrane Phosphoprotein Reference proteome Transferase
modified	[InstanceEdit:12187927] Wright, Adam, 2024-03-12
name	NMT1
otherIdentifier	11722195_s_at 11722196_x_at 11722197_at 11751589_a_at 16834883 201157_PM_s_at 201157_s_at 201158_PM_at 201158_at 201159_PM_s_at 201159_s_at 3723265 3723268 3723269 3723270 3723281 3723285 3723287 3723288 3723289 3723290 3723291 3723297 3723298 3723300 3723302 3723303 3723304 3723305 3723306 3723307 3723312 3723314 38999_s_at 39000_at 4836 8007715 A_14_P103416 A_14_P117222 A_23_P107373 A_24_P14010 GE54377 GO:0001701 GO:0003824 GO:0004379 GO:0005515 GO:0005737 GO:0005739 GO:0005829 GO:0005886 GO:0006499 GO:0006886 GO:0007005 GO:0012501 GO:0016020 GO:0016740 GO:0016746 GO:0018008 GO:0018030 GO:0019107 GO:0022400 GO:0023052 GO:0036211 GO:0042180 GO:0043226 GO:0048856 GO:0061024 GO:0072657 GO:0140096 GO:1900740 HMNXSV003030620 HMNXSV003048730 Hs.111039.0.A1_3p_a_at ILMN_1762678 M86707_at PH_hs_0023902 TC17000577.hg U79285_at g10835072_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-60306] NMT1 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8990278] ENSEMBL:ENSG00000136448 NMT1 [ReferenceDNASequence:11031625] KEGG Gene (Homo sapiens):4836 NMT1 [ReferenceDNASequence:11281553] NCBI Gene:4836 NMT1 [ReferenceDNASequence:11281554] BioGPS Gene:4836 NMT1 [ReferenceDNASequence:11281555] CTD Gene:4836 NMT1 [ReferenceDNASequence:11281556] dbSNP Gene:4836 NMT1 [ReferenceDNASequence:11281557] Monarch:4836 NMT1 [ReferenceDNASequence:11352780] ENSEMBL_homo_sapiens_GENE:ENSG00000136448.13 NMT1 [ReferenceDNASequence:11518490] UCSC:P30419 NMT1 [ReferenceDNASequence:11803135] OMIM:160993 NMT1 [ReferenceDNASequence:11869682] HGNC:7857 NMT1 [ReferenceDNASequence:12189480] COSMIC (genes):NMT1 NMT1
referenceTranscript	[ReferenceRNASequence:11457165] RefSeq:NM_021079.4 NMT1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	NMT1_HUMAN A8K7C1 Q9UE09
sequenceLength	496
species	[Species:48887] Homo sapiens
url	https://purl.uniprot.org/uniprot/P30419

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-60306] NMT1 [cytosol]
(interactor)	[UndirectedInteraction:12312233] UniProt:Q9BR61 <-> UniProt:P30419 (IntAct) [UndirectedInteraction:12229239] UniProt:P04601 <-> UniProt:P30419 (IntAct)

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