UniProt:Q92887 ABCC2

chain
  • chain:1-1545
checksum C5F8984FFCDF9799
comment
  • FUNCTION ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed:10421658). Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). Transport various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed:10220572, PubMed:11500505, PubMed:12441801). Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine (PubMed:10220572, PubMed:11500505).TISSUE SPECIFICITY Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.SIMILARITY Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
crossReference
databaseName UniProt
dbId 59561
description
  • recommendedName: ATP-binding cassette sub-family C member 2 ecNumber evidence="8 16"7.6.2.-/ecNumber ecNumber evidence="7 13 14"7.6.2.2/ecNumber ecNumber evidence="7 13"7.6.2.3/ecNumber alternativeName: Canalicular multidrug resistance protein alternativeName: fullName evidence="25"Canalicular multispecific organic anion transporter 1 alternativeName: Multidrug resistance-associated protein 2
displayName UniProt:Q92887 ABCC2
geneName
  • ABCC2
  • CMOAT
  • CMOAT1
  • CMRP
  • MRP2
identifier Q92887
isSequenceChanged false
keyword
  • ATP-binding
  • Cell membrane
  • Disease variant
  • Glycoprotein
  • Membrane
  • Nucleotide-binding
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • Translocase
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:11703684] Shorser, Solomon, 2021-05-28
name
  • ABCC2
otherIdentifier
  • 0003710605
  • 11730409_at
  • 11759031_at
  • 1244
  • 16708192
  • 206155_at
  • 3260448
  • 3260449
  • 3260451
  • 3260452
  • 3260453
  • 3260454
  • 3260456
  • 3260458
  • 3260459
  • 3260461
  • 3260462
  • 3260463
  • 3260464
  • 3260465
  • 3260466
  • 3260467
  • 3260468
  • 3260469
  • 3260472
  • 3260474
  • 3260475
  • 3260476
  • 3260477
  • 3260478
  • 3260480
  • 3260481
  • 3260483
  • 3260484
  • 3260485
  • 3260486
  • 3260487
  • 3260489
  • 3260490
  • 3260492
  • 3260493
  • 3260496
  • 3260497
  • 3260498
  • 3260499
  • 3260500
  • 33721_at
  • 67977_at
  • 7929779
  • A_14_P113705
  • A_23_P158976
  • A_23_P44569
  • GE62639
  • GO:0000003
  • GO:0000166
  • GO:0003013
  • GO:0003674
  • GO:0005515
  • GO:0005524
  • GO:0005575
  • GO:0005886
  • GO:0005887
  • GO:0006790
  • GO:0006810
  • GO:0006855
  • GO:0006950
  • GO:0006954
  • GO:0006979
  • GO:0007165
  • GO:0007565
  • GO:0008150
  • GO:0008514
  • GO:0008559
  • GO:0009056
  • GO:0009408
  • GO:0009986
  • GO:0010468
  • GO:0010629
  • GO:0015127
  • GO:0015431
  • GO:0015694
  • GO:0015711
  • GO:0015721
  • GO:0015722
  • GO:0015723
  • GO:0015732
  • GO:0016020
  • GO:0016021
  • GO:0016324
  • GO:0016887
  • GO:0016999
  • GO:0019748
  • GO:0019904
  • GO:0022857
  • GO:0030644
  • GO:0031427
  • GO:0031526
  • GO:0032355
  • GO:0032496
  • GO:0033762
  • GO:0034641
  • GO:0035690
  • GO:0038183
  • GO:0042167
  • GO:0042178
  • GO:0042493
  • GO:0042592
  • GO:0042626
  • GO:0042910
  • GO:0043167
  • GO:0043627
  • GO:0044281
  • GO:0046581
  • GO:0046618
  • GO:0046685
  • GO:0046691
  • GO:0048545
  • GO:0050787
  • GO:0055085
  • GO:0070327
  • GO:0070633
  • GO:0071222
  • GO:0071347
  • GO:0071354
  • GO:0071356
  • GO:0071549
  • GO:0071716
  • GO:0097327
  • GO:0098656
  • GO:0120188
  • GO:0150104
  • GO:1901086
  • GO:1904486
  • GO:1990961
  • GO:1990962
  • HMNXSV003017571
  • HMNXSV003037426
  • ILMN_1676278
  • ILMN_1780706
  • PH_hs_0011436
  • TC10000715.hg
  • U49248_at
  • g4557480_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • MRP2_HUMAN
  • B2RMT8
  • Q14022
  • Q5T2B1
  • Q92500
  • Q92798
  • Q99663
  • Q9UMS2
sequenceLength 1545
species [Species:48887] Homo sapiens
url http://purl.uniprot.org/uniprot/Q92887
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