Reactome | UniProt:Q92887 ABCC2

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UniProt:Q92887 ABCC2 Show undefined attributes

chain	chain:1-1545
checksum	C5F8984FFCDF9799
comment	FUNCTION ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed:10421658). Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed:10220572, PubMed:11500505, PubMed:12441801). Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine (PubMed:10220572, PubMed:11500505).CATALYTIC ACTIVITY ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.CATALYTIC ACTIVITY an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphateCATALYTIC ACTIVITY ATP + H2O + taurolithocholate 3-sulfate(in) = ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out)CATALYTIC ACTIVITY ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphateCATALYTIC ACTIVITY 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphateCATALYTIC ACTIVITY ATP + bilirubin-glucuronoside(in) + H2O = ADP + bilirubin-glucuronoside(out) + H(+) + phosphateCATALYTIC ACTIVITY ATP + bilirubin-bisglucuronoside(in) + H2O = ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphateBIOPHYSICOCHEMICAL PROPERTIES Localized to the apical membrane of enterocytes.TISSUE SPECIFICITY Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver. Expressed in small intestine (PubMed:28408210).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.ONLINE INFORMATION Database for mutations in ABC proteins
crossReference	[DatabaseIdentifier:10969618] Pharos - Targets:Q92887 [DatabaseIdentifier:10981600] Guide to Pharmacology - Targets:780 [DatabaseIdentifier:11043004] IntEnz:7.6.2.2 [DatabaseIdentifier:11047906] OpenTargets:ENSG00000023839 [DatabaseIdentifier:11594818] RefSeq:NP_000383.1 [DatabaseIdentifier:11804084] PRO:Q92887 [DatabaseIdentifier:11841115] GeneCards:Q92887 [DatabaseIdentifier:11852522] ZINC - Substances:MRP2_HUMAN [DatabaseIdentifier:11855245] ZINC - FDA approved:MRP2_HUMAN [DatabaseIdentifier:11856274] ZINC - World Drugs:MRP2_HUMAN [DatabaseIdentifier:11860551] ZINC - Predictions - Purchasable:MRP2_HUMAN [DatabaseIdentifier:11863395] ZINC target:Q92887 [DatabaseIdentifier:11881333] Orphanet:15054 [DatabaseIdentifier:11887113] HMDB Protein:HMDBP01658 [DatabaseIdentifier:11892269] HPA:ENSG00000023839-ABCC2 [DatabaseIdentifier:11939878] Ensembl:ENSG00000023839 [DatabaseIdentifier:11939879] Ensembl:ENSP00000497274 [DatabaseIdentifier:11939880] Ensembl:ENST00000647814
databaseName	UniProt
dbId	59561
description	recommendedName: ATP-binding cassette sub-family C member 2 ecNumber evidence="9 17"7.6.2.- ecNumber evidence="8 14 15"7.6.2.2 ecNumber evidence="8 14"7.6.2.3 alternativeName: Canalicular multidrug resistance protein alternativeName: fullName evidence="27"Canalicular multispecific organic anion transporter 1 alternativeName: Multidrug resistance-associated protein 2
displayName	UniProt:Q92887 ABCC2
geneName	ABCC2 CMOAT CMOAT1 CMRP MRP2
identifier	Q92887
isSequenceChanged	false
keyword	ATP-binding Cell membrane Disease variant Glycoprotein Lipid transport Membrane Nucleotide-binding Phosphoprotein Reference proteome Repeat Translocase Transmembrane Transmembrane helix Transport
modified	[InstanceEdit:12187927] Wright, Adam, 2024-03-12
name	ABCC2
otherIdentifier	11730409_at 11759031_at 1244 16708192 206155_PM_at 206155_at 3260448 3260449 3260451 3260452 3260453 3260454 3260456 3260458 3260459 3260461 3260462 3260463 3260464 3260465 3260466 3260467 3260468 3260469 3260472 3260474 3260475 3260476 3260477 3260478 3260480 3260481 3260483 3260484 3260485 3260486 3260487 3260489 3260490 3260492 3260493 3260496 3260497 3260498 3260499 3260500 33721_at 67977_at 7929779 A_14_P113705 A_23_P158976 A_23_P44569 GE62639 GO:0000166 GO:0003013 GO:0003824 GO:0005215 GO:0005515 GO:0005524 GO:0005886 GO:0006805 GO:0006855 GO:0006869 GO:0008514 GO:0008559 GO:0009986 GO:0010629 GO:0015127 GO:0015431 GO:0015721 GO:0015723 GO:0016020 GO:0016324 GO:0016787 GO:0016887 GO:0022857 GO:0042167 GO:0042626 GO:0042910 GO:0043225 GO:0046581 GO:0046618 GO:0055085 GO:0070633 GO:0071716 GO:0098656 GO:0140359 GO:0140657 GO:0150104 GO:1990962 HMNXSV003017571 HMNXSV003037426 ILMN_1676278 PH_hs_0011436 TC10000715.hg U49248_at g4557480_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-5679033] ABCC2 R768W [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5679021] ABCC2 R1066* [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5679024] ABCC2 R1150H [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5679030] ABCC2 I1173F [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-375571] ABCC2 [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8991403] ENSEMBL:ENSG00000023839 ABCC2 [ReferenceDNASequence:11023014] KEGG Gene (Homo sapiens):1244 ABCC2 [ReferenceDNASequence:11231632] NCBI Gene:1244 ABCC2 [ReferenceDNASequence:11231633] BioGPS Gene:1244 ABCC2 [ReferenceDNASequence:11231634] CTD Gene:1244 ABCC2 [ReferenceDNASequence:11231635] dbSNP Gene:1244 ABCC2 [ReferenceDNASequence:11231636] Monarch:1244 ABCC2 [ReferenceDNASequence:11344133] ENSEMBL_homo_sapiens_GENE:ENSG00000023839.12 ABCC2 [ReferenceDNASequence:11509850] UCSC:Q92887 ABCC2 [ReferenceDNASequence:11794923] OMIM:601107 ABCC2 [ReferenceDNASequence:11868474] HGNC:53 ABCC2 [ReferenceDNASequence:12191309] COSMIC (genes):ABCC2 ABCC2
referenceTranscript	[ReferenceRNASequence:11440445] RefSeq:NM_000392.4 ABCC2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	MRP2_HUMAN B2RMT8 Q14022 Q5T2B1 Q92500 Q92798 Q99663 Q9UMS2
sequenceLength	1545
species	[Species:48887] Homo sapiens
url	https://purl.uniprot.org/uniprot/Q92887

Referrals

(interactor)	[UndirectedInteraction:12313507] UniProt:P19838 <-> UniProt:Q92887 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-5679033] ABCC2 R768W [plasma membrane] [EntityWithAccessionedSequence:R-HSA-5679021] ABCC2 R1066* [plasma membrane] [EntityWithAccessionedSequence:R-HSA-5679024] ABCC2 R1150H [plasma membrane] [EntityWithAccessionedSequence:R-HSA-5679030] ABCC2 I1173F [plasma membrane] [EntityWithAccessionedSequence:R-HSA-375571] ABCC2 [plasma membrane]
(referenceSequence)	[ReplacedResidue:5679016] L-arginine 768 replaced with L-tryptophan [NonsenseMutation:5679039] Nonsense mutation at L-arginine 1066 [ReplacedResidue:5679038] L-arginine 1150 replaced with L-histidine [ReplacedResidue:5679027] L-isoleucine 1173 replaced with L-phenylalanine