Reactome | UniProt:P14780 MMP9

Schema > ReferenceGeneProduct > Entries

UniProt:P14780 MMP9 Show undefined attributes

chain	signal peptide:1-19 propeptide:20-93 chain:94- chain:107-707 propeptide:-707
checksum	2165AC8CA1466209
comment	FUNCTION Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (PubMed:2551898, PubMed:1480034, PubMed:12879005). Could play a role in bone osteoclastic resorption (By similarity). Cleaves KiSS1 at a Gly-\|-Leu bond (PubMed:12879005). Cleaves NINJ1 to generate the Secreted ninjurin-1 form (PubMed:32883094). Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (PubMed:1480034). Degrades fibronectin but not laminin or Pz-peptide.CATALYTIC ACTIVITY Cleavage of gelatin types I and V and collagen types IV and V.COFACTOR Binds 2 Zn(2+) ions per subunit.COFACTOR Binds 3 Ca(2+) ions per subunit.ACTIVITY REGULATION Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1.SUBUNIT Exists as monomer or homodimer; disulfide-linked (PubMed:1281792, PubMed:7683678). Exists also as heterodimer with LCN2 (PubMed:1281792, PubMed:7683678). Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1 (PubMed:16512877).SUBUNIT (Microbial infection) Interacts with Staphylococcus aureus protein SSL5; this interaction inhibits MMP9 activity.INTERACTION Detected in neutrophils (at protein level) (PubMed:7683678). Produced by normal alveolar macrophages and granulocytes.INDUCTION Activated by 4-aminophenylmercuric acetate and phorbol ester. Up-regulated by ARHGEF4, SPATA13 and APC via the JNK signaling pathway in colorectal tumor cells.INDUCTION (Microbial infection) Expression induced by M.bovis MPB83 (at protein level) (PubMed:20800577).DOMAIN The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.PTM Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.PTM N- and O-glycosylated.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status.SIMILARITY Belongs to the peptidase M10A family.
crossReference	[DatabaseIdentifier:10971536] Pharos - Targets:P14780 [DatabaseIdentifier:10982000] Guide to Pharmacology - Targets:1633 [DatabaseIdentifier:11054093] OpenTargets:ENSG00000100985 [DatabaseIdentifier:11618974] RefSeq:NP_004985.2 [DatabaseIdentifier:11767004] PDB:1GKC [DatabaseIdentifier:11767014] PDB:1GKD [DatabaseIdentifier:11767016] PDB:1ITV [DatabaseIdentifier:11767028] PDB:1L6J [DatabaseIdentifier:11767030] PDB:2OVX [DatabaseIdentifier:11767040] PDB:2OVZ [DatabaseIdentifier:11767042] PDB:2OW0 [DatabaseIdentifier:11767053] PDB:2OW1 [DatabaseIdentifier:11767055] PDB:2OW2 [DatabaseIdentifier:11767065] PDB:4H1Q [DatabaseIdentifier:11767067] PDB:4H2E [DatabaseIdentifier:11767068] PDB:4H3X [DatabaseIdentifier:11767079] PDB:4H82 [DatabaseIdentifier:11767081] PDB:4HMA [DatabaseIdentifier:11767093] PDB:4JIJ [DatabaseIdentifier:11767095] PDB:4JQG [DatabaseIdentifier:11767106] PDB:4WZV [DatabaseIdentifier:11767107] PDB:4XCT [DatabaseIdentifier:11767109] PDB:5CUH [DatabaseIdentifier:11767121] PDB:5I12 [DatabaseIdentifier:11767123] PDB:5TH6 [DatabaseIdentifier:11767135] PDB:5TH9 [DatabaseIdentifier:11767137] PDB:5UE3 [DatabaseIdentifier:11767148] PDB:5UE4 [DatabaseIdentifier:11767150] PDB:6ESM [DatabaseIdentifier:11811259] PRO:P14780 [DatabaseIdentifier:11842302] GeneCards:P14780 [DatabaseIdentifier:11853000] ZINC - Substances:MMP9_HUMAN [DatabaseIdentifier:11855427] ZINC - FDA approved:MMP9_HUMAN [DatabaseIdentifier:11856496] ZINC - World Drugs:MMP9_HUMAN [DatabaseIdentifier:11857620] ZINC - Metabolites:MMP9_HUMAN [DatabaseIdentifier:11858484] ZINC - Biogenic:MMP9_HUMAN [DatabaseIdentifier:11859680] ZINC - Investigational:MMP9_HUMAN [DatabaseIdentifier:11861057] ZINC - Predictions - Purchasable:MMP9_HUMAN [DatabaseIdentifier:11863906] ZINC target:P14780 [DatabaseIdentifier:11881944] Orphanet:18601 [DatabaseIdentifier:11887956] HMDB Protein:HMDBP02128 [DatabaseIdentifier:11894072] HPA:ENSG00000100985-MMP9 [DatabaseIdentifier:11964651] Ensembl:ENSG00000100985 [DatabaseIdentifier:11964652] Ensembl:ENSP00000361405 [DatabaseIdentifier:11964653] Ensembl:ENST00000372330
databaseName	UniProt
dbId	59395
description	recommendedName: Matrix metalloproteinase-9 shortName: MMP-9 ecNumber evidence="17"3.4.24.35 alternativeName: 92 kDa gelatinase alternativeName: fullName evidence="35"92 kDa type IV collagenase alternativeName: Gelatinase B shortName: GELB component recommendedName: fullName evidence="34"67 kDa matrix metalloproteinase-9 /component component recommendedName: fullName evidence="34"82 kDa matrix metalloproteinase-9 /component
displayName	UniProt:P14780 MMP9
geneName	MMP9 CLG4B
identifier	P14780
isSequenceChanged	false
keyword	3D-structure Calcium Collagen degradation Direct protein sequencing Disulfide bond Extracellular matrix Glycoprotein Hydrolase Metal-binding Metalloprotease Protease Reference proteome Repeat Secreted Signal Zinc Zymogen
modified	[InstanceEdit:12187927] Wright, Adam, 2024-03-12
name	MMP9
otherIdentifier	11719657_a_at 16914395 203936_PM_s_at 203936_s_at 31859_at 3887212 3887213 3887214 3887215 3887216 3887217 3887218 3887219 3887220 3887221 3887222 3887223 3887224 3887226 3887227 3887228 3887229 3887230 4318 8063115 A_14_P117083 A_23_P40174 GE57525 GO:0001501 GO:0001934 GO:0003824 GO:0004175 GO:0004222 GO:0004252 GO:0005515 GO:0005518 GO:0005576 GO:0005615 GO:0006508 GO:0006915 GO:0006954 GO:0007005 GO:0007566 GO:0008233 GO:0008237 GO:0008270 GO:0012501 GO:0016477 GO:0016787 GO:0022414 GO:0022617 GO:0023052 GO:0030154 GO:0030198 GO:0030225 GO:0030312 GO:0030574 GO:0031012 GO:0031410 GO:0034614 GO:0035987 GO:0036211 GO:0042802 GO:0043065 GO:0043066 GO:0043226 GO:0043388 GO:0045742 GO:0046872 GO:0048013 GO:0048856 GO:0048870 GO:0050896 GO:0051549 GO:0055085 GO:0062023 GO:0070062 GO:0071222 GO:0071276 GO:0071492 GO:0090200 GO:0140096 GO:0150077 GO:1900122 GO:1904645 GO:1904707 GO:1904724 GO:1904813 GO:2000697 GO:2001243 GO:2001258 GO:2001268 HMNXSV003043897 ILMN_1796316 J05070_at PH_hs_0009143 TC20000363.hg g4826835_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-1604713] MMP9(20-106) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1604685] MMP9(20-59) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1604376] MMP9(20-707) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1604699] MMP9(60-106) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1604726] MMP9(60-707) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6800181] MMP9 [tertiary granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6800973] MMP9 [ficolin-1-rich granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-668812] MMP9(107-707) [extracellular region] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8948370] ENSEMBL:ENSG00000100985 MMP9 [ReferenceDNASequence:11032679] KEGG Gene (Homo sapiens):4318 MMP9 [ReferenceDNASequence:11261566] NCBI Gene:4318 MMP9 [ReferenceDNASequence:11261567] BioGPS Gene:4318 MMP9 [ReferenceDNASequence:11261568] CTD Gene:4318 MMP9 [ReferenceDNASequence:11261569] dbSNP Gene:4318 MMP9 [ReferenceDNASequence:11261570] Monarch:4318 MMP9 [ReferenceDNASequence:11354658] ENSEMBL_homo_sapiens_GENE:ENSG00000100985.7 MMP9 [ReferenceDNASequence:11509961] UCSC:P14780 MMP9 [ReferenceDNASequence:11801990] OMIM:120361 MMP9 [ReferenceDNASequence:11869660] HGNC:7176 MMP9 [ReferenceDNASequence:12198490] COSMIC (genes):MMP9 MMP9
referenceTranscript	[ReferenceRNASequence:11450041] RefSeq:NM_004994.2 MMP9
schemaClass	ReferenceGeneProduct
secondaryIdentifier	MMP9_HUMAN B2R7V9 Q3LR70 Q8N725 Q9H4Z1 Q9UCJ9 Q9UCL1 Q9UDK2
sequenceLength	707
species	[Species:48887] Homo sapiens
url	https://purl.uniprot.org/uniprot/P14780

Referrals

(referenceEntity)

(interactor)