UniProt:P21108 PRPS1L1

chain
  • initiator methionine:
  • chain:2-318
checksum 6A4EDC798FB3B296
comment
  • FUNCTION Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.CATALYTIC ACTIVITY ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)COFACTOR Activated by magnesium and inorganic phosphate.PATHWAY Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.SUBUNIT Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity).TISSUE SPECIFICITY Testis.SIMILARITY Belongs to the ribose-phosphate pyrophosphokinase family.CAUTION According to PubMed:2168892, this sequence initiates from a non-AUG codon; N-terminal ACG codon did serve as a start codon.
crossReference
databaseName UniProt
dbId 58227
description
  • recommendedName: Ribose-phosphate pyrophosphokinase 3 ecNumber: 2.7.6.1 alternativeName: Phosphoribosyl pyrophosphate synthase 1-like 1 shortName: PRPS1-like 1 alternativeName: Phosphoribosyl pyrophosphate synthase III shortName: PRS-III
displayName UniProt:P21108 PRPS1L1
geneName
  • PRPS1L1
  • PRPS3
  • PRPSL
identifier P21108
isSequenceChanged false
keyword
  • ATP-binding
  • Direct protein sequencing
  • Kinase
  • Magnesium
  • Metal-binding
  • Nucleotide biosynthesis
  • Nucleotide-binding
  • Reference proteome
  • Transferase
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • PRPS1L1
otherIdentifier
  • 11734347_at
  • 17055599
  • 215486_PM_at
  • 215486_at
  • 221823
  • 3040179
  • 3040180
  • 3040181
  • 3040182
  • 31485_at
  • 3986516
  • 3986517
  • 3986524
  • 8138435
  • A_32_P192823
  • GE57982
  • GO:0000166
  • GO:0000287
  • GO:0002189
  • GO:0003824
  • GO:0004749
  • GO:0005524
  • GO:0005575
  • GO:0005737
  • GO:0006015
  • GO:0006164
  • GO:0008584
  • GO:0009156
  • GO:0009165
  • GO:0016301
  • GO:0016310
  • GO:0016740
  • GO:0022414
  • GO:0042803
  • GO:0044249
  • GO:0046872
  • GO:0048856
  • GO:0055086
  • GO:0071704
  • GO:1901135
  • HMNXSV003005963
  • Hs.169284.0.S1_3p_at
  • ILMN_1655155
  • ILMN_2232953
  • M57423_f_at
  • TC07001170.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PRPS3_HUMAN
  • Q6P5P6
sequenceLength 318
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/P21108
Cite Us!