UniProt:Q9ULD8 KCNH3

chain
  • chain:1-1083
checksum EF35C8968D7418CC
comment
  • FUNCTION Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.SUBUNIT The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.INTERACTION Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex, occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus.DOMAIN The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.SIMILARITY Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily.
crossReference
databaseName UniProt
dbId 57925
description
  • recommendedName: Potassium voltage-gated channel subfamily H member 3 alternativeName: Brain-specific eag-like channel 1 shortName: BEC1 alternativeName: Ether-a-go-go-like potassium channel 2 shortName: ELK channel 2 shortName: ELK2 alternativeName: Voltage-gated potassium channel subunit Kv12.2
displayName UniProt:Q9ULD8 KCNH3
geneName
  • KCNH3
  • KIAA1282
identifier Q9ULD8
isSequenceChanged false
keyword
  • Glycoprotein
  • Ion channel
  • Ion transport
  • Membrane
  • Potassium
  • Potassium channel
  • Potassium transport
  • Reference proteome
  • Transmembrane
  • Transmembrane helix
  • Transport
  • Voltage-gated channel
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • KCNH3
otherIdentifier
  • 11726917_at
  • 16750837
  • 223726_PM_at
  • 223726_at
  • 23416
  • 3414030
  • 3414031
  • 3414032
  • 3414034
  • 3414036
  • 3414037
  • 3414038
  • 3414040
  • 3414041
  • 3414042
  • 3414046
  • 3414047
  • 3414048
  • 3414049
  • 3414050
  • 3414054
  • 3414055
  • 3414056
  • 3414057
  • 3414058
  • 3414061
  • 3414062
  • 3414064
  • 3414065
  • 3414066
  • 3414067
  • 3414068
  • 3414069
  • 3414070
  • 3414071
  • 53681_at
  • 7955231
  • A_23_P87917
  • A_33_P3253672
  • GE53866
  • GO:0005215
  • GO:0005216
  • GO:0005249
  • GO:0005267
  • GO:0005515
  • GO:0005886
  • GO:0006811
  • GO:0006813
  • GO:0016020
  • GO:0034220
  • GO:0034702
  • GO:0042391
  • GO:0055085
  • GO:0071805
  • HMNXSV003018801
  • HMNXSV003057791
  • ILMN_1704063
  • PH_hs_0003991
  • TC12000374.hg
  • g5804783_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • KCNH3_HUMAN
  • Q9UQ06
sequenceLength 1083
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/Q9ULD8
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