Reactome | UniProt:Q01813 PFKP

Schema > ReferenceGeneProduct > Entries

UniProt:Q01813 PFKP Show undefined attributes

chain	chain:1-784
checksum	22522E77E9AF80F6
comment	FUNCTION Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.CATALYTIC ACTIVITY ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)COFACTOR Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.PATHWAY Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.SUBUNIT Homo- and heterotetramers (By similarity). Phosphofructokinase (PFK) enzyme functions as a tetramer composed of different combinations of 3 types of subunits, called PFKM (where M stands for Muscle), PFKL (Liver) and PFKP (Platelet). The composition of the PFK tetramer differs according to the tissue type it is present in. In muscles, it is composed of 4 PFKM subunits (also called M4). In the liver, the predominant form is a tetramer of PFKL subunits (L4). In erythrocytes, both PFKM and PFKL subunits randomly tetramerize to form M4, L4 and other combinations (ML3, M2L2, M3L). In platelets, brain and fibroblasts, PFK contains a higher proportion of PFKP subunits. The kinetic and regulatory properties of the tetrameric enzyme are dependent on the subunit composition, hence can vary across tissues (Probable). Interacts with ATG4B; promoting phosphorylation of ATG4B (PubMed:33607258).INTERACTION Phosphorylation at Ser-386 promotes interaction with ATG4B.PTM GlcNAcylation decreases enzyme activity.MISCELLANEOUS In human PFK exists as a system of 3 types of subunits, PFKM (muscle), PFKL (liver) and PFKP (platelet) isoenzymes.SIMILARITY Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
crossReference	[DatabaseIdentifier:10970826] Pharos - Targets:Q01813 [DatabaseIdentifier:11043699] IntEnz:2.7.1.11 [DatabaseIdentifier:11051506] OpenTargets:ENSG00000067057 [DatabaseIdentifier:11608280] RefSeq:NP_001229268.1 [DatabaseIdentifier:11608291] RefSeq:NP_002618.1 [DatabaseIdentifier:11764818] PDB:4RH3 [DatabaseIdentifier:11764824] PDB:4U1R [DatabaseIdentifier:11764830] PDB:4WL0 [DatabaseIdentifier:11764836] PDB:4XYJ [DatabaseIdentifier:11764842] PDB:4XYK [DatabaseIdentifier:11764848] PDB:4XZ2 [DatabaseIdentifier:11764855] PDB:7TFF [DatabaseIdentifier:11808105] PRO:Q01813 [DatabaseIdentifier:11842775] GeneCards:Q01813 [DatabaseIdentifier:11887728] HMDB Protein:HMDBP00734 [DatabaseIdentifier:11893681] HPA:ENSG00000067057-PFKP [DatabaseIdentifier:11975272] Ensembl:ENSP00000370517 [DatabaseIdentifier:11975273] Ensembl:ENST00000381125 [DatabaseIdentifier:11975274] Ensembl:ENSG00000067057
databaseName	UniProt
dbId	57811
description	recommendedName: fullName evidence="4"ATP-dependent 6-phosphofructokinase, platelet type shortName evidence="4"ATP-PFK shortName: PFK-P ecNumber evidence="4"2.7.1.11 alternativeName: 6-phosphofructokinase type C alternativeName: Phosphofructo-1-kinase isozyme C shortName: PFK-C alternativeName: fullName evidence="4"Phosphohexokinase
displayName	UniProt:Q01813 PFKP
geneName	PFKP PFKF
identifier	Q01813
isSequenceChanged	false
keyword	3D-structure Acetylation Allosteric enzyme Alternative splicing ATP-binding Cytoplasm Glycolysis Glycoprotein Kinase Magnesium Metal-binding Nucleotide-binding Phosphoprotein Reference proteome Transferase
modified	[InstanceEdit:12187927] Wright, Adam, 2024-03-12
name	PFKP
otherIdentifier	11715971_a_at 16701841 201037_PM_at 201037_at 3232350 3232351 3232357 3232361 3232365 3232366 3232367 3232368 3232373 3232375 3232377 3232378 3232380 3232382 3232383 3232384 3232387 3232391 3232392 3232408 3232409 3232410 3232411 3232413 3232414 3232415 3232416 3232417 39175_at 5214 7925876 A_14_P109474 A_14_P117531 A_14_P121863 A_23_P46928 A_33_P3413962 D25328_at GO:0000166 GO:0003824 GO:0003872 GO:0005515 GO:0005524 GO:0005576 GO:0005615 GO:0005634 GO:0005737 GO:0005829 GO:0005945 GO:0005975 GO:0006002 GO:0006091 GO:0006096 GO:0008152 GO:0016020 GO:0016208 GO:0016301 GO:0016310 GO:0016740 GO:0030388 GO:0042802 GO:0043226 GO:0044877 GO:0045296 GO:0046872 GO:0048029 GO:0055086 GO:0061621 GO:0070062 GO:0070095 GO:1901135 GO:1990830 HMNXSV003030309 ILMN_1805737 PH_hs_0026522 TC10000022.hg g11321600_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-71452] PFKP [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8994424] ENSEMBL:ENSG00000067057 PFKP [ReferenceDNASequence:11024276] KEGG Gene (Homo sapiens):5214 PFKP [ReferenceDNASequence:11237709] NCBI Gene:5214 PFKP [ReferenceDNASequence:11237710] BioGPS Gene:5214 PFKP [ReferenceDNASequence:11237711] CTD Gene:5214 PFKP [ReferenceDNASequence:11237712] dbSNP Gene:5214 PFKP [ReferenceDNASequence:11237713] Monarch:5214 PFKP [ReferenceDNASequence:11346761] ENSEMBL_homo_sapiens_GENE:ENSG00000067057.19 PFKP [ReferenceDNASequence:11514829] UCSC:Q01813 PFKP [ReferenceDNASequence:11795785] OMIM:171840 PFKP [ReferenceDNASequence:11870135] HGNC:8878 PFKP [ReferenceDNASequence:12197001] COSMIC (genes):PFKP PFKP
referenceTranscript	[ReferenceRNASequence:11469876] RefSeq:NM_001242339.1 PFKP [ReferenceRNASequence:11469881] RefSeq:NM_002627.4 PFKP
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PFKAP_HUMAN B3KS15 Q5VSR7 Q5VSR8
sequenceLength	784
species	[Species:48887] Homo sapiens
url	https://purl.uniprot.org/uniprot/Q01813

Referrals

(interactor)	[UndirectedInteraction:12321321] UniProt:Q8NEZ3 <-> UniProt:Q01813 (IntAct) [UndirectedInteraction:12299867] UniProt:Q5S007 <-> UniProt:Q01813 (IntAct) [UndirectedInteraction:12264181] UniProt:Q9HBG6 <-> UniProt:Q01813 (IntAct) [UndirectedInteraction:12245353] UniProt:P31152 <-> UniProt:Q01813 (IntAct) [UndirectedInteraction:12215661] UniProt:P10636-8 <-> UniProt:Q01813 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-71452] PFKP [cytosol]