UniProt:P48200 IREB2

chain
  • chain:1-963
checksum 051228C6CE5362FD
comment
  • FUNCTION RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.SUBUNIT Interacts with RBCK1 isoform 1 and isoform 2 only in iron-rich conditions (PubMed:12629548). Interacts (when associated with the 4Fe-4S) with FBXL5 (PubMed:19762596, PubMed:19762597). Interacts with CIAO1 and CIAO2A (PubMed:23891004).PTM Ubiquitinated and degraded by the proteasome in presence of high level of iron and oxygen. Ubiquitinated by a SCF complex containing FBXL5. Upon iron and oxygen depletion FBXL5 is degraded, preventing ubiquitination and allowing its RNA-binding activity.SIMILARITY Belongs to the aconitase/IPM isomerase family.
crossReference
databaseName UniProt
dbId 57473
description
  • recommendedName: Iron-responsive element-binding protein 2 shortName:IRE-BP 2 alternativeName: Iron regulatory protein 2 shortName:IRP2
displayName UniProt:P48200 IREB2
geneName
  • IREB2
identifier P48200
isSequenceChanged false
keyword
  • 3D-structure
  • 4Fe-4S
  • Alternative splicing
  • Cytoplasm
  • Disease variant
  • Iron
  • Iron-sulfur
  • Metal-binding
  • Neurodegeneration
  • Reference proteome
  • RNA-binding
  • Ubl conjugation
modified [InstanceEdit:11703169] Weiser, JD, 2021-09-15
name
  • IREB2
otherIdentifier
  • 0000870070
  • 0005220102
  • 11721363_x_at
  • 11721364_s_at
  • 11721365_a_at
  • 11752798_a_at
  • 11756521_a_at
  • 11762719_at
  • 1555476_at
  • 16803501
  • 214666_x_at
  • 225892_at
  • 242261_at
  • 3444509
  • 3444545
  • 3603337
  • 3603341
  • 3603348
  • 3603349
  • 3603352
  • 3603355
  • 3603357
  • 3603359
  • 3603360
  • 3603361
  • 3603362
  • 3603363
  • 3603364
  • 3603365
  • 3603366
  • 3603367
  • 3603368
  • 3603369
  • 3603371
  • 3603373
  • 3603374
  • 3603375
  • 3603376
  • 3603377
  • 3603378
  • 3603379
  • 3603380
  • 3603381
  • 3603382
  • 3603384
  • 3603385
  • 3658
  • 40345_at
  • 4053677
  • 54426_r_at
  • 61344_at
  • 63505_at
  • 7985166
  • A_14_P133217
  • A_23_P106497
  • A_33_P3221528
  • GE58993
  • GO:0002376
  • GO:0003674
  • GO:0003723
  • GO:0003729
  • GO:0003994
  • GO:0005515
  • GO:0005575
  • GO:0005622
  • GO:0005737
  • GO:0005739
  • GO:0005829
  • GO:0006091
  • GO:0006099
  • GO:0006101
  • GO:0006412
  • GO:0006417
  • GO:0006782
  • GO:0006810
  • GO:0006826
  • GO:0006879
  • GO:0008150
  • GO:0009058
  • GO:0009791
  • GO:0010468
  • GO:0016829
  • GO:0017148
  • GO:0030154
  • GO:0030316
  • GO:0030350
  • GO:0030371
  • GO:0034101
  • GO:0034641
  • GO:0042592
  • GO:0043167
  • GO:0043226
  • GO:0044281
  • GO:0046872
  • GO:0048856
  • GO:0050892
  • GO:0051536
  • GO:0051539
  • GO:0055072
  • HMNXSV003003049
  • Hs.295789.0.A1_3p_at
  • Hs.295789.0.A1_3p_x_at
  • Hs.295789.1.A1_3p_at
  • Hs.94149.0.S1_3p_at
  • Hs2.370324.1.S1_3p_at
  • ILMN_1726554
  • PH_hs_0017771
  • TC15000729.hg
  • TC15002301.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • IREB2_HUMAN
  • A0A0A6YY96
  • A8KAC7
  • E1CJT9
  • H0YKU0
  • Q13095
  • Q1HE21
  • Q59FQ7
  • Q8WVK6
  • Q9UF17
sequenceLength 963
species [Species:48887] Homo sapiens
url http://purl.uniprot.org/uniprot/P48200
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