UniProt:P40305 IFI27

chain
  • transit peptide:1-33
  • chain:34-122
checksum A424B2EDEAA678A3
comment
  • FUNCTION Probable adapter protein involved in different biological processes (PubMed:22427340, PubMed:27194766). Part of the signaling pathways that lead to apoptosis (PubMed:18330707, PubMed:27673746, PubMed:24970806). Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 (PubMed:18330707, PubMed:27673746). Also functions in TNFSF10-induced apoptosis (PubMed:24970806). May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340). May thereby play a role in the vascular response to injury (By similarity). In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed:27194766, PubMed:27777077). May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766, PubMed:27777077). Promotes also virus-induced pyroptosis by activating CASP3 in the mitochondria after 'Lys-6'-linked ubiquitination by TRIM21 (PubMed:36426955).SUBUNIT Homodimer (PubMed:27673746). Interacts with hepatitis C virus/HCV non-structural protein NS5A; promotes the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766). Interacts with SKP2; promotes the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766). Interacts with NR4A1 (PubMed:22427340). May interact with BCL2 (PubMed:27673746).INTERACTION Exclusive localizations in either the nucleus or the mitochondrion have been reported.ALTERNATIVE PRODUCTS Up-regulated by type-I and type-II interferons.PTM Ubiquitinated by TRIM21 via 'Lys-6'-linked ubiquitin chains leading to IFI27 mitochondrial migration.MISCELLANEOUS Major isoform in blood and cervix.SIMILARITY Belongs to the IFI6/IFI27 family.
crossReference
databaseName UniProt
dbId 57393
description
  • recommendedName: fullName evidence="16"Interferon alpha-inducible protein 27, mitochondrial shortName: p27 alternativeName: Interferon alpha-induced 11.5 kDa protein alternativeName: fullName evidence="14"Interferon-stimulated gene 12a protein shortName evidence="14"ISG12(a) shortName evidence="15"ISG12A
displayName UniProt:P40305 IFI27
geneName
  • IFI27
identifier P40305
isSequenceChanged false
keyword
  • Alternative splicing
  • Antiviral defense
  • Apoptosis
  • Endoplasmic reticulum
  • Host-virus interaction
  • Immunity
  • Innate immunity
  • Isopeptide bond
  • Membrane
  • Mitochondrion
  • Nucleus
  • Reference proteome
  • Transcription
  • Transcription regulation
  • Transit peptide
  • Transmembrane
  • Transmembrane helix
  • Ubl conjugation
modified [InstanceEdit:12187927] Wright, Adam, 2024-03-12
name
  • IFI27
otherIdentifier
  • 11715893_s_at
  • 11757480_x_at
  • 16787814
  • 202411_PM_at
  • 202411_at
  • 3429
  • 3549576
  • 3549577
  • 3549578
  • 3549579
  • 3549582
  • 3549583
  • 3549588
  • 3549590
  • 3549592
  • 3549593
  • 3549594
  • 425_at
  • 48864_at
  • 7976443
  • A_23_P48513
  • A_24_P270460
  • GE81525
  • GO:0000122
  • GO:0002376
  • GO:0003674
  • GO:0005515
  • GO:0005521
  • GO:0005634
  • GO:0005635
  • GO:0005637
  • GO:0005739
  • GO:0005741
  • GO:0005783
  • GO:0005789
  • GO:0006351
  • GO:0006355
  • GO:0006886
  • GO:0006913
  • GO:0006915
  • GO:0012501
  • GO:0016020
  • GO:0023052
  • GO:0030163
  • GO:0031966
  • GO:0036211
  • GO:0042802
  • GO:0043161
  • GO:0043226
  • GO:0044827
  • GO:0045087
  • GO:0046825
  • GO:0051607
  • GO:0060090
  • GO:0060337
  • GO:0061629
  • GO:0070269
  • GO:0070936
  • GO:0097190
  • GO:0097191
  • GO:0098542
  • HMNXSV003045213
  • ILMN_2058782
  • PH_hs_0014293
  • TC14000584.hg
  • TC14001821.hg
  • X67325_at
  • g5031780_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • IFI27_HUMAN
  • A0A087WZF8
  • A8K0H0
  • Q53YA6
  • Q6IEC1
  • Q7Z5R0
  • Q7Z5R1
  • Q7Z5R2
  • Q96BK3
  • Q9H4B1
sequenceLength 122
species [Species:48887] Homo sapiens
url https://purl.uniprot.org/uniprot/P40305
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